Expression of LY6D in cancer - Summary - The Human Protein Atlas

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LY6D

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LY6D
Gene description	Lymphocyte antigen 6 complex, locus D
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (cervical cancer, head and neck cancer, urothelial cancer)
HPA (cell line):	Cell line enriched (A-431)
HPA (normal tissue):	Group enriched (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA024755 , HPA064317
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (cervical cancer, head and neck cancer, urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA024755	HPA064317

GENE INFORMATION
Gene name	LY6D (HGNC Symbol)
Synonyms	E48
Description	Lymphocyte antigen 6 complex, locus D (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	142784880 - 142786592
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167656 (version 83.38)
Entrez gene	8581
UniProt	Q14210 (UniProt - Evidence at protein level)
neXtProt	NX_Q14210
Antibodypedia	LY6D antibodies

PROTEIN BROWSER

LY6D-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LY6D-001 ENSP00000301263 ENST00000301263	Q14210 [Direct mapping] Lymphocyte antigen 6D Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030098 [lymphocyte differentiation] GO:0031225 [anchored component of membrane] GO:0035634 [response to stilbenoid] Show all	128 aa 13.3 kDa	Yes	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.