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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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EEF2
  • TISSUE

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    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

EEF2

Gene description

Eukaryotic translation elongation factor 2

Protein class

Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 3 antibodies.
HPA040534 , HPA057351 , CAB007795
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PROGNOSTIC SUMMARY

Prognostic marker in endometrial cancer (favourable) and renal cancer (favourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA040534
HPA057351
CAB007795

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong cytoplasmic immunoreactivity with additional membranous staining in several cases.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues generally showed moderate cytoplasmic staining with additional membranous positivity in several cases. Follicular adenomas of thyroid and several cases of testicular cancers were strongly stained. Weak staining was observed in several cases of gliomas and cervical cancers.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Cancer tissues showed moderate to strong cytoplasmic immunoreactivity. Several renal cancers were negative.

GENE INFORMATION

Gene name

EEF2 (HGNC Symbol)

Synonyms

EEF-2, EF2

Description

Eukaryotic translation elongation factor 2 (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

Chromosome

19

Cytoband

p13.3

Chromosome location (bp)

3976056 - 3985469

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167658 (version 83.38)

Entrez gene

1938

UniProt

P13639 (UniProt - Evidence at protein level)

neXtProt

NX_P13639

Antibodypedia

EEF2 antibodies

PROTEIN BROWSER

EEF2-001
EEF2-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

EEF2-001
ENSP00000307940
ENST00000309311
P13639 [Direct mapping]
Elongation factor 2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002039 [p53 binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002931 [response to ischemia]
GO:0003009 [skeletal muscle contraction]
GO:0003723 [RNA binding]
GO:0003746 [translation elongation factor activity]
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005844 [polysome]
GO:0005886 [plasma membrane]
GO:0006412 [translation]
GO:0006414 [translational elongation]
GO:0007568 [aging]
GO:0008097 [5S rRNA binding]
GO:0010467 [gene expression]
GO:0014009 [glial cell proliferation]
GO:0014076 [response to fluoxetine]
GO:0016020 [membrane]
GO:0016235 [aggresome]
GO:0017183 [peptidyl-diphthamide biosynthetic process from peptidyl-histidine]
GO:0019901 [protein kinase binding]
GO:0030529 [ribonucleoprotein complex]
GO:0032355 [response to estradiol]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0035914 [skeletal muscle cell differentiation]
GO:0042542 [response to hydrogen peroxide]
GO:0042788 [polysomal ribosome]
GO:0043022 [ribosome binding]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0045121 [membrane raft]
GO:0045471 [response to ethanol]
GO:0045727 [positive regulation of translation]
GO:0051015 [actin filament binding]
GO:0051593 [response to folic acid]
GO:0070062 [extracellular exosome]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2000767 [positive regulation of cytoplasmic translation]
Show all
858 aa
95.3 kDa
No 0
EEF2-011
ENSP00000471265
ENST00000600794
M0R0I6 [Direct mapping]
Elongation factor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
85 aa
9.4 kDa
No 0

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