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CHAF1A

GENERAL INFORMATION

Gene name

 CHAF1A

Gene description

 Chromatin assembly factor 1, subunit A (p150)

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB015186
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PROGNOSTIC SUMMARY
Prognostic marker in stomach cancer (favourable) and cervical cancer (favourable).
Stomach cancer p<0.001
Cervical cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB015186

GENE INFORMATION

Gene name

 CHAF1A (HGNC Symbol)

Synonyms

 CAF-1, CAF1, CAF1B, CAF1P150, MGC71229, P150

Description

 Chromatin assembly factor 1, subunit A (p150) (HGNC Symbol)

Entrez gene summary

 Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 4402662 - 4445018

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167670 (version 83.38)

Entrez gene

 10036

UniProt

 Q13111 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13111

Antibodypedia

 CHAF1A antibodies

PROTEIN BROWSER
CHAF1A-001
CHAF1A-004
CHAF1A-005
CHAF1A-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CHAF1A-001
ENSP00000301280
ENST00000301280
Q13111 [Direct mapping]
Chromatin assembly factor 1 subunit A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000790 [nuclear chromatin]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006260 [DNA replication]
GO:0006281 [DNA repair]
GO:0006335 [DNA replication-dependent nucleosome assembly]
GO:0006461 [protein complex assembly]
GO:0007049 [cell cycle]
GO:0031497 [chromatin assembly]
GO:0033186 [CAF-1 complex]
GO:0042802 [identical protein binding]
GO:0043234 [protein complex]
GO:0051082 [unfolded protein binding]
GO:0070087 [chromo shadow domain binding]
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 956 aa
106.9 kDa 		No 0
CHAF1A-004
ENSP00000465142
ENST00000585854
K7EJF1 [Direct mapping]
Chromatin assembly factor 1 subunit A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 151 aa
16.4 kDa 		No 0
CHAF1A-005
ENSP00000467296
ENST00000587739
K7EPA1 [Direct mapping]
Chromatin assembly factor 1 subunit A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 292 aa
33.7 kDa 		No 0
CHAF1A-008
ENSP00000466475
ENST00000589648
K7EME9 [Direct mapping]
Chromatin assembly factor 1 subunit A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus]
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 47 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.