Cell atlas - NXN - The Human Protein Atlas

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NXN

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Golgi apparatus

Human cell
	Cytosol
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	NXN
Gene description	Nucleoredoxin
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol & the Golgi apparatus.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (supported), Cytosol (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA023566
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol & the Golgi apparatus.

Main location

Golgi apparatus (supported), Cytosol (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA023566	A-431	Golgi apparatus
	HPA023566	A-431	Cytosol
	HPA023566	U-2 OS	Golgi apparatus
	HPA023566	U-2 OS	Cytosol
	HPA023566	U-251 MG	Golgi apparatus
	HPA023566	U-251 MG	Cytosol

GENE INFORMATION
Gene name	NXN (HGNC Symbol)
Synonyms	FLJ12614, NRX
Description	Nucleoredoxin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the thioredoxin superfamily, a group of small, multifunctional redox-active proteins. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. The encoded protein acts a redox-dependent regulator of the Wnt signaling pathway and is involved in cell growth and differentiation. [provided by RefSeq, Sep 2015]
Chromosome	17
Cytoband	p13.3
Chromosome location (bp)	799313 - 979770
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167693 (version 83.38)
Entrez gene	64359
UniProt	Q6DKJ4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6DKJ4
Antibodypedia	NXN antibodies

PROTEIN BROWSER

NXN-001	NXN-002	NXN-003	NXN-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NXN-001 ENSP00000337443 ENST00000336868	Q6DKJ4 [Direct mapping] Nucleoredoxin Show all	Enzymes ENZYME proteins Oxidoreductases THUMBUP predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004791 [thioredoxin-disulfide reductase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016055 [Wnt signaling pathway] GO:0030154 [cell differentiation] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0031397 [negative regulation of protein ubiquitination] GO:0047134 [protein-disulfide reductase activity] GO:0055114 [oxidation-reduction process] GO:0072358 [cardiovascular system development] Show all	435 aa 48.4 kDa	No	0
NXN-002 ENSP00000446446 ENST00000537628	A0A0C4DGI2 [Direct mapping] Nucleoredoxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 20.9 kDa	No	0
NXN-003 ENSP00000461562 ENST00000571684	I3L4V6 [Direct mapping] Nucleoredoxin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		230 aa 25.9 kDa	No	0
NXN-005 ENSP00000461038 ENST00000575801	Q6DKJ4 [Direct mapping] Nucleoredoxin Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005829 [cytosol] GO:0016055 [Wnt signaling pathway] GO:0030154 [cell differentiation] GO:0030178 [negative regulation of Wnt signaling pathway] GO:0031397 [negative regulation of protein ubiquitination] GO:0047134 [protein-disulfide reductase activity] GO:0055114 [oxidation-reduction process] GO:0072358 [cardiovascular system development] Show all	327 aa 36.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.