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RILP

GENERAL INFORMATION

Gene name

 RILP

Gene description

 Rab interacting lysosomal protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, HMC-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), urothelial cancer (favourable) and breast cancer (favourable).
Renal cancer p<0.001
Urothelial cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RILP (HGNC Symbol)

Synonyms

 FLJ31193

Description

 Rab interacting lysosomal protein (HGNC Symbol)

Entrez gene summary

 This gene encodes a lysosomal protein that interacts with RAB7, a small GTPase that controls transport to endocytic degradative compartments. Studies using mutant forms of the two proteins suggest that this protein represents a downstream effector for RAB7, and both proteins act together in the regulation of late endocytic traffic. A unique region of this protein has also been shown to be involved in the regulation of lysosomal morphology. [provided by RefSeq, Sep 2011]

Chromosome

 17

Cytoband

 p13.3

Chromosome location (bp)

 1646145 - 1650077

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167705 (version 83.38)

Entrez gene

 83547

UniProt

 Q96NA2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96NA2

Antibodypedia

 RILP antibodies

PROTEIN BROWSER
RILP-001
RILP-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RILP-001
ENSP00000301336
ENST00000301336
Q96NA2 [Direct mapping]
Rab-interacting lysosomal protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005770 [late endosome]
GO:0008333 [endosome to lysosome transport]
GO:0010796 [regulation of multivesicular body size]
GO:0015031 [protein transport]
GO:0017137 [Rab GTPase binding]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0030670 [phagocytic vesicle membrane]
GO:0031902 [late endosome membrane]
GO:0032509 [endosome transport via multivesicular body sorting pathway]
GO:0042177 [negative regulation of protein catabolic process]
GO:0043234 [protein complex]
GO:0045022 [early endosome to late endosome transport]
GO:0045732 [positive regulation of protein catabolic process]
GO:0070676 [intralumenal vesicle formation]
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 401 aa
44.2 kDa 		No 0
RILP-004
ENSP00000459101
ENST00000574810
I3L1U0 [Direct mapping]
Rab-interacting lysosomal protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 226 aa
24.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.