Cell atlas - TRPV3 - The Human Protein Atlas

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TRPV3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Centrosome
	Cytosol
	Plasma membrane

Human cell
	Centrosome
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TRPV3
Gene description	Transient receptor potential cation channel, subfamily V, member 3
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane. In addition localized to the cytosol & centrosome.
RNA cell category	Cell line enhanced (RH-30, T-47d, BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)
Additional location	In addition localized to the Centrosome (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA069550
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (RH-30, T-47d, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane. In addition localized to the cytosol & centrosome.

Main location

Plasma membrane (approved)

Additional location

Centrosome (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA069550	CACO-2	Plasma membrane
	HPA069550	RH-30	Centrosome
	HPA069550	RH-30	Cytosol
	HPA069550	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	TRPV3 (HGNC Symbol)
Synonyms	VRL3
Description	Transient receptor potential cation channel, subfamily V, member 3 (HGNC Symbol)
Entrez gene summary	This gene product belongs to a family of nonselective cation channels that function in a variety of processes, including temperature sensation and vasoregulation. The thermosensitive members of this family are expressed in subsets of sensory neurons that terminate in the skin, and are activated at distinct physiological temperatures. This channel is activated at temperatures between 22 and 40 degrees C. This gene lies in close proximity to another family member gene on chromosome 17, and the two encoded proteins are thought to associate with each other to form heteromeric channels. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	3510502 - 3557995
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167723 (version 83.38)
Entrez gene	162514
UniProt	Q8NET8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NET8
Antibodypedia	TRPV3 antibodies

PROTEIN BROWSER

TRPV3-001	TRPV3-002	TRPV3-003	TRPV3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TRPV3-001 ENSP00000461518 ENST00000576742	Q8NET8 [Direct mapping] Transient receptor potential cation channel subfamily V member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0042636 [negative regulation of hair cycle] GO:0043235 [receptor complex] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	790 aa 90.6 kDa	No	6
TRPV3-002 ENSP00000301365 ENST00000301365	Q8NET8 [Direct mapping] Transient receptor potential cation channel subfamily V member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005261 [cation channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0009266 [response to temperature stimulus] GO:0009408 [response to heat] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0042636 [negative regulation of hair cycle] GO:0043235 [receptor complex] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] GO:0090280 [positive regulation of calcium ion import] Show all	791 aa 90.7 kDa	No	6
TRPV3-003 ENSP00000460215 ENST00000572519	Q8NET8 [Direct mapping] Transient receptor potential cation channel subfamily V member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Show all	GO:0005216 [ion channel activity] GO:0005262 [calcium channel activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0006811 [ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0042636 [negative regulation of hair cycle] GO:0043235 [receptor complex] GO:0055085 [transmembrane transport] GO:0070588 [calcium ion transmembrane transport] Show all	765 aa 87.7 kDa	No	6
TRPV3-201 ENSP00000483947 ENST00000616411	A0A087X170 [Direct mapping] Transient receptor potential cation channel subfamily V member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Show all	GO:0005216 [ion channel activity] GO:0005515 [protein binding] GO:0006811 [ion transport] GO:0009266 [response to temperature stimulus] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] Show all	775 aa 89.2 kDa	No	6

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.