Expression of CYB5D2 in cancer - Summary - The Human Protein Atlas

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CYB5D2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYB5D2
Gene description	Cytochrome b5 domain containing 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA042299
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (favourable), pancreatic cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Liver cancer p<0.001 Pancreatic cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042299

GENE INFORMATION
Gene name	CYB5D2 (HGNC Symbol)
Synonyms	MGC32124
Description	Cytochrome b5 domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.2
Chromosome location (bp)	4143168 - 4187310
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167740 (version 83.38)
Entrez gene	124936
UniProt	Q8WUJ1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8WUJ1
Antibodypedia	CYB5D2 antibodies

PROTEIN BROWSER

CYB5D2-001	CYB5D2-002	CYB5D2-003	CYB5D2-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYB5D2-001 ENSP00000301391 ENST00000301391	Q8WUJ1 [Direct mapping] Neuferricin Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0020037 [heme binding] GO:0045666 [positive regulation of neuron differentiation] Show all	264 aa 28.7 kDa	Yes	0
CYB5D2-002 ENSP00000458903 ENST00000575251	Q8WUJ1 [Direct mapping] Neuferricin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0020037 [heme binding] Show all	152 aa 16.9 kDa	No	0
CYB5D2-003 ENSP00000458352 ENST00000577075	Q8WUJ1 [Direct mapping] Neuferricin Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005576 [extracellular region] GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0020037 [heme binding] Show all	152 aa 16.9 kDa	No	0
CYB5D2-004 ENSP00000461090 ENST00000573984	I3L497 [Direct mapping] Neuferricin Show all	Predicted intracellular proteins Show all	GO:0012505 [endomembrane system] GO:0016020 [membrane] GO:0020037 [heme binding] Show all	106 aa 11.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.