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KLK4

GENERAL INFORMATION

Gene name

 KLK4

Gene description

 Kallikrein-related peptidase 4

Protein class

 Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enhanced (CAPAN-2, HaCaT)
HPA (normal tissue):Tissue enriched (prostate)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Granular expression in prostate

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA051839
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051839

GENE INFORMATION

Gene name

 KLK4 (HGNC Symbol)

Synonyms

 EMSP, EMSP1, KLK-L1, PRSS17, PSTS

Description

 Kallikrein-related peptidase 4 (HGNC Symbol)

Entrez gene summary

 Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In some tissues its expression is hormonally regulated. The expression pattern of a similar mouse protein in murine developing teeth supports a role for the protein in the degradation of enamel proteins. Several transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Dec 2014]

Chromosome

 19

Cytoband

 q13.41

Chromosome location (bp)

 50906352 - 50910738

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167749 (version 83.38)

Entrez gene

 9622

UniProt

 Q9Y5K2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5K2

Antibodypedia

 KLK4 antibodies

PROTEIN BROWSER
KLK4-001
KLK4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLK4-001
ENSP00000326159
ENST00000324041
A0A0C4DFQ5 [Direct mapping]
Kallikrein 4 (Prostase, enamel matrix, prostate), isoform CRA_a; Kallikrein-4
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
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GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0022617 [extracellular matrix disassembly]
GO:0030163 [protein catabolic process]
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 254 aa
27 kDa 		Yes 0
KLK4-201
ENSP00000399448
ENST00000431178
Q9Y5K2 [Direct mapping]
Kallikrein-4
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Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Potential drug targets
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GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0006508 [proteolysis]
GO:0008236 [serine-type peptidase activity]
GO:0046872 [metal ion binding]
GO:0097186 [amelogenesis]
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 110 aa
11.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.