Expression of KLK2 in cancer - Summary - The Human Protein Atlas

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KLK2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLK2
Gene description	Kallikrein-related peptidase 2
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enhanced (NB-4)
HPA (normal tissue):	Tissue enriched (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 1 antibody. HPA000764
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000764

GENE INFORMATION
Gene name	KLK2
Synonyms
Description	Kallikrein-related peptidase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the grandular kallikrein protein family. Kallikreins are a subgroup of serine proteases that are clustered on chromosome 19. Members of this family are involved in a diverse array of biological functions. The protein encoded by this gene is a highly active trypsin-like serine protease that selectively cleaves at arginine residues. This protein is primarily expressed in prostatic tissue and is responsible for cleaving pro-prostate-specific antigen into its enzymatically active form. This gene is highly expressed in prostate tumor cells and may be a prognostic maker for prostate cancer risk. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	19
Cytoband	q13.33
Chromosome location (bp)	50861568 - 50880567
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167751 (version 83.38)
Entrez gene	3817
UniProt	P20151 (UniProt - Evidence at protein level)
neXtProt	NX_P20151
Antibodypedia	KLK2 antibodies

PROTEIN BROWSER

KLK2-001	KLK2-003	KLK2-015	KLK2-016	KLK2-019	KLK2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK2-001 ENSP00000313581 ENST00000325321	P20151 [Direct mapping] Kallikrein-2 A0A024R4J4 [Target identity:100%; Query identity:100%] Kallikrein 2, prostatic, isoform CRA_a Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	261 aa 28.7 kDa	Yes	0
KLK2-003 ENSP00000350748 ENST00000358049	P20151 [Direct mapping] Kallikrein-2 A0A024R4N3 [Target identity:100%; Query identity:100%] Kallikrein 2, prostatic, isoform CRA_b Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	223 aa 24.7 kDa	Yes	0
KLK2-015 ENSP00000469318 ENST00000600690	M0QXQ7 [Direct mapping] Kallikrein-2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	122 aa 13.1 kDa	Yes	0
KLK2-016 ENSP00000472852 ENST00000593493	M0R2W5 [Direct mapping] Kallikrein-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		23 aa 2.7 kDa	No	0
KLK2-019 ENSP00000471323 ENST00000599568	M0R0M4 [Direct mapping] Kallikrein-2 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	44 aa 4.9 kDa	No	0
KLK2-201 ENSP00000375686 ENST00000391810	P20151 [Direct mapping] Kallikrein-2 Show all	Enzymes ENZYME proteins Hydrolases Peptidases Serine-type peptidases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005622 [intracellular] GO:0006508 [proteolysis] GO:0007264 [small GTPase mediated signal transduction] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0070062 [extracellular exosome] Show all	159 aa 17.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.