Expression of KLK5 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	KLK5
Gene description	Kallikrein-related peptidase 5
Protein class	Cancer-related genes Enzymes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (ovarian cancer)
HPA (cell line):	Group enriched (A-431, HaCaT)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct expression in superficial layers of skin. Extracellular deposits and cytoplasmic expression in mammary glands.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 3 antibodies. HPA014343 , CAB025503 , CAB026341
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), endometrial cancer (unfavourable) and lung cancer (unfavourable).
Urothelial cancer p<0.001 Endometrial cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA014343	CAB025503	CAB026341

GENE INFORMATION
Gene name	KLK5 (HGNC Symbol)
Synonyms	KLK-L2, SCTE
Description	Kallikrein-related peptidase 5 (HGNC Symbol)
Entrez gene summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its expression is up-regulated by estrogens and progestins. The encoded protein is secreted and may be involved in desquamation in the epidermis. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	50943303 - 50953093
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167754 (version 83.38)
Entrez gene	25818
UniProt	Q9Y337 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y337
Antibodypedia	KLK5 antibodies

PROTEIN BROWSER

KLK5-001	KLK5-004	KLK5-005	KLK5-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK5-001 ENSP00000337733 ENST00000336334	Q9Y337 [Direct mapping] Kallikrein-5 A0A024R4G4 [Target identity:100%; Query identity:100%] Kallikrein 5, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0097209 [epidermal lamellar body] Show all	293 aa 32 kDa	Yes	0
KLK5-004 ENSP00000471966 ENST00000593428	Q9Y337 [Direct mapping] Kallikrein-5 A0A024R4G4 [Target identity:100%; Query identity:100%] Kallikrein 5, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0097209 [epidermal lamellar body] Show all	293 aa 32 kDa	Yes	0
KLK5-005 ENSP00000375685 ENST00000391809	Q9Y337 [Direct mapping] Kallikrein-5 A0A024R4G4 [Target identity:100%; Query identity:100%] Kallikrein 5, isoform CRA_a Show all	Enzymes Peptidases Serine-type peptidases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002803 [positive regulation of antibacterial peptide production] GO:0004252 [serine-type endopeptidase activity] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008236 [serine-type peptidase activity] GO:0008544 [epidermis development] GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway] GO:0097209 [epidermal lamellar body] Show all	293 aa 32 kDa	Yes	0
KLK5-006 ENSP00000469439 ENST00000594846	M0QXX2 [Direct mapping] Kallikrein-5 Show all	THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	205 aa 22.4 kDa	Yes	0