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KLK6

GENERAL INFORMATION

Gene name

 KLK6

Gene description

 Kallikrein-related peptidase 6

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (ovarian cancer)
HPA (cell line):Group enriched (A-431, CAPAN-2)
HPA (normal tissue):Group enriched (cerebral cortex, esophagus, fallopian tube, tonsil)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable), urothelial cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Endometrial cancer p<0.001
Urothelial cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (ovarian cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 KLK6 (HGNC Symbol)

Synonyms

 Bssp, Klk7, neurosin, PRSS18, PRSS9

Description

 Kallikrein-related peptidase 6 (HGNC Symbol)

Entrez gene summary

 Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.41

Chromosome location (bp)

 50958631 - 50969673

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167755 (version 83.38)

Entrez gene

 5653

UniProt

 Q92876 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92876

Antibodypedia

 KLK6 antibodies

PROTEIN BROWSER
KLK6-001
KLK6-003
KLK6-006
KLK6-201
KLK6-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KLK6-001
ENSP00000309148
ENST00000310157
Q92876 [Direct mapping]
Kallikrein-6
A0A024R4J8 [Target identity:100%; Query identity:100%]
Kallikrein 6 (Neurosin, zyme), isoform CRA_b
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0009611 [response to wounding]
GO:0015630 [microtubule cytoskeleton]
GO:0016485 [protein processing]
GO:0016540 [protein autoprocessing]
GO:0030574 [collagen catabolic process]
GO:0031965 [nuclear membrane]
GO:0042246 [tissue regeneration]
GO:0042445 [hormone metabolic process]
GO:0042552 [myelination]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0045171 [intercellular bridge]
GO:0045595 [regulation of cell differentiation]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0070997 [neuron death]
Show all
 244 aa
26.9 kDa 		Yes 0
KLK6-003
ENSP00000366047
ENST00000376851
Q92876 [Direct mapping]
Kallikrein-6
A0A024R4J8 [Target identity:100%; Query identity:100%]
Kallikrein 6 (Neurosin, zyme), isoform CRA_b
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0008233 [peptidase activity]
GO:0009611 [response to wounding]
GO:0010975 [regulation of neuron projection development]
GO:0015630 [microtubule cytoskeleton]
GO:0016485 [protein processing]
GO:0016540 [protein autoprocessing]
GO:0030574 [collagen catabolic process]
GO:0031965 [nuclear membrane]
GO:0042246 [tissue regeneration]
GO:0042445 [hormone metabolic process]
GO:0042552 [myelination]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0045171 [intercellular bridge]
GO:0045595 [regulation of cell differentiation]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0070997 [neuron death]
Show all
 244 aa
26.9 kDa 		Yes 0
KLK6-006
ENSP00000470482
ENST00000594641
Q92876 [Direct mapping]
Kallikrein-6
A0A024R4J8 [Target identity:100%; Query identity:100%]
Kallikrein 6 (Neurosin, zyme), isoform CRA_b
Show all
Enzymes
   Peptidases
   Serine-type peptidases
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0009611 [response to wounding]
GO:0015630 [microtubule cytoskeleton]
GO:0016485 [protein processing]
GO:0016540 [protein autoprocessing]
GO:0030574 [collagen catabolic process]
GO:0031965 [nuclear membrane]
GO:0042246 [tissue regeneration]
GO:0042445 [hormone metabolic process]
GO:0042552 [myelination]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0045171 [intercellular bridge]
GO:0045595 [regulation of cell differentiation]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0070997 [neuron death]
Show all
 244 aa
26.9 kDa 		Yes 0
KLK6-201
ENSP00000366049
ENST00000376853
E7ETY0 [Direct mapping]
Kallikrein-6
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0006508 [proteolysis]
GO:0016485 [protein processing]
Show all
 120 aa
13.1 kDa 		Yes 0
KLK6-202
ENSP00000375684
ENST00000391808
Q92876 [Direct mapping]
Kallikrein-6
Show all
Enzymes
   Peptidases
   Serine-type peptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004252 [serine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005783 [endoplasmic reticulum]
GO:0006508 [proteolysis]
GO:0007417 [central nervous system development]
GO:0009611 [response to wounding]
GO:0015630 [microtubule cytoskeleton]
GO:0016485 [protein processing]
GO:0016540 [protein autoprocessing]
GO:0030574 [collagen catabolic process]
GO:0031965 [nuclear membrane]
GO:0042246 [tissue regeneration]
GO:0042445 [hormone metabolic process]
GO:0042552 [myelination]
GO:0042982 [amyloid precursor protein metabolic process]
GO:0045171 [intercellular bridge]
GO:0045595 [regulation of cell differentiation]
GO:0045745 [positive regulation of G-protein coupled receptor protein signaling pathway]
GO:0070997 [neuron death]
Show all
 137 aa
15.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.