Expression of KLK11 in cancer - Summary - The Human Protein Atlas

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KLK11

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KLK11
Gene description	Kallikrein-related peptidase 11
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, EFO-21, HaCaT)
HPA (normal tissue):	Tissue enhanced (esophagus, skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in superficial layers of skin and in salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Approved based on 1 antibody. CAB026340
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and pancreatic cancer (unfavourable).
Endometrial cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB026340

GENE INFORMATION
Gene name	KLK11 (HGNC Symbol)
Synonyms	PRSS20, TLSP
Description	Kallikrein-related peptidase 11 (HGNC Symbol)
Entrez gene summary	Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Alternate splicing of this gene results in multiple transcript variants encoding distinct isoforms which are differentially expressed.[provided by RefSeq, Nov 2009]
Chromosome	19
Cytoband	q13.41
Chromosome location (bp)	51022216 - 51028039
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167757 (version 83.38)
Entrez gene	11012
UniProt	Q9UBX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBX7
Antibodypedia	KLK11 antibodies

PROTEIN BROWSER

KLK11-001	KLK11-002	KLK11-003	KLK11-004	KLK11-007	KLK11-008	KLK11-009	KLK11-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KLK11-001 ENSP00000324269 ENST00000319720	Q9UBX7 [Direct mapping] Kallikrein-11 Kallikrein-11 inactive chain 1 Kallikrein-11 inactive chain 2 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070062 [extracellular exosome] Show all	250 aa 27.5 kDa	Yes	0
KLK11-002 ENSP00000473047 ENST00000594768	Q9UBX7 [Direct mapping] Kallikrein-11 Kallikrein-11 inactive chain 1 Kallikrein-11 inactive chain 2 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070062 [extracellular exosome] Show all	282 aa 31.1 kDa	Yes	0
KLK11-003 ENSP00000413958 ENST00000453757	Q9UBX7 [Direct mapping] Kallikrein-11 Kallikrein-11 inactive chain 1 Kallikrein-11 inactive chain 2 Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070062 [extracellular exosome] Show all	250 aa 27.5 kDa	Yes	0
KLK11-004 ENSP00000375680 ENST00000391804	Q9UBX7 [Direct mapping] Kallikrein-11 Kallikrein-11 inactive chain 1 Kallikrein-11 inactive chain 2 Show all	Enzymes Peptidases Serine-type peptidases SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005615 [extracellular space] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0008236 [serine-type peptidase activity] GO:0070062 [extracellular exosome] Show all	275 aa 30.2 kDa	Yes	0
KLK11-007 ENSP00000470113 ENST00000593681	M0QYW4 [Direct mapping] Kallikrein-11 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	141 aa 15.4 kDa	No	0
KLK11-008 ENSP00000470574 ENST00000598799	M0QZI8 [Direct mapping] Kallikrein-11 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	170 aa 18.8 kDa	Yes	0
KLK11-009 ENSP00000471636 ENST00000600362	M0R151 [Direct mapping] Kallikrein-11 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	109 aa 12 kDa	Yes	0
KLK11-010 ENSP00000470783 ENST00000601671	M0QZV0 [Direct mapping] Kallikrein-11 Show all	SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0006508 [proteolysis] Show all	68 aa 7.6 kDa	Yes	0

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The Project

The Human Protein Atlas

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