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KRT1

GENERAL INFORMATION

Gene name

 KRT1

Gene description

 Keratin 1, type II

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (head and neck cancer, melanoma)
HPA (cell line):Group enriched (HaCaT, hTCEpi)
HPA (normal tissue):Tissue enriched (skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in differentiating squamous epithelium.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA017917 , HPA062908 , CAB002153
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, melanoma)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA017917
HPA062908
CAB002153

GENE INFORMATION

Gene name

 KRT1 (HGNC Symbol)

Synonyms

 EHK1, KRT1A

Description

 Keratin 1, type II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 52674736 - 52680407

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167768 (version 83.38)

Entrez gene

 3848

UniProt

 P04264 (UniProt - Evidence at protein level)

neXtProt

 NX_P04264

Antibodypedia

 KRT1 antibodies

PROTEIN BROWSER
KRT1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT1-001
ENSP00000252244
ENST00000252244
P04264 [Direct mapping]
Keratin, type II cytoskeletal 1
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001867 [complement activation, lectin pathway]
GO:0001895 [retina homeostasis]
GO:0004872 [receptor activity]
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005856 [cytoskeleton]
GO:0005882 [intermediate filament]
GO:0005886 [plasma membrane]
GO:0006979 [response to oxidative stress]
GO:0016020 [membrane]
GO:0030246 [carbohydrate binding]
GO:0031012 [extracellular matrix]
GO:0042730 [fibrinolysis]
GO:0045095 [keratin filament]
GO:0045765 [regulation of angiogenesis]
GO:0050728 [negative regulation of inflammatory response]
GO:0061436 [establishment of skin barrier]
GO:0070062 [extracellular exosome]
GO:0072562 [blood microparticle]
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 644 aa
66 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.