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OTUB1

GENERAL INFORMATION

Gene name

 OTUB1

Gene description

 OTU deubiquitinase, ubiquitin aldehyde binding 1

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA039176 , CAB072836
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA039176
CAB072836

GENE INFORMATION

Gene name

 OTUB1 (HGNC Symbol)

Synonyms

 FLJ20113, FLJ40710

Description

 OTU deubiquitinase, ubiquitin aldehyde binding 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a member of the OTU (ovarian tumor) superfamily of predicted cysteine proteases. The encoded protein is a highly specific ubiquitin iso-peptidase, and cleaves ubiquitin from branched poly-ubiquitin chains but not from ubiquitinated substrates. It interacts with another ubiquitin protease and an E3 ubiquitin ligase that inhibits cytokine gene transcription in the immune system. It is proposed to function in specific ubiquitin-dependent pathways, possibly by providing an editing function for polyubiquitin chain growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 63985853 - 64001811

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167770 (version 83.38)

Entrez gene

 55611

UniProt

 Q96FW1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96FW1

Antibodypedia

 OTUB1 antibodies

PROTEIN BROWSER
OTUB1-001
OTUB1-003
OTUB1-005
OTUB1-008
OTUB1-010
OTUB1-012
OTUB1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OTUB1-001
ENSP00000444357
ENST00000538426
Q96FW1 [Direct mapping]
Ubiquitin thioesterase OTUB1
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002250 [adaptive immune response]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
GO:0019784 [NEDD8-specific protease activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
GO:0070062 [extracellular exosome]
GO:0071108 [protein K48-linked deubiquitination]
GO:0071347 [cellular response to interleukin-1]
GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination]
GO:2000780 [negative regulation of double-strand break repair]
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 271 aa
31.3 kDa 		No 0
OTUB1-003
ENSP00000441328
ENST00000543988
F5GYN4 [Direct mapping]
Ubiquitin thioesterase OTUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
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 241 aa
28.1 kDa 		No 0
OTUB1-005
ENSP00000439142
ENST00000541478
F5H3F0 [Direct mapping]
Ubiquitin thioesterase OTUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 170 aa
19.4 kDa 		No 0
OTUB1-008
ENSP00000437453
ENST00000543004
F5H6Q1 [Direct mapping]
Ubiquitin thioesterase OTUB1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
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 280 aa
32.3 kDa 		No 0
OTUB1-010
ENSP00000440211
ENST00000535715
F5GYJ8 [Direct mapping]
Ubiquitin thioesterase OTUB1
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   MEMSAT3 predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
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 286 aa
32.4 kDa 		No 0
OTUB1-012
ENSP00000402551
ENST00000428192
Q96FW1 [Direct mapping]
Ubiquitin thioesterase OTUB1
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002250 [adaptive immune response]
GO:0004843 [ubiquitin-specific protease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
GO:0019784 [NEDD8-specific protease activity]
GO:0031625 [ubiquitin protein ligase binding]
GO:0043130 [ubiquitin binding]
GO:0070062 [extracellular exosome]
GO:0071108 [protein K48-linked deubiquitination]
GO:1901315 [negative regulation of histone H2A K63-linked ubiquitination]
GO:2000780 [negative regulation of double-strand break repair]
Show all
 271 aa
31.3 kDa 		No 0
OTUB1-201
ENSP00000416973
ENST00000422031
J3KR44 [Direct mapping]
Ubiquitin thioesterase OTUB1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016579 [protein deubiquitination]
GO:0016787 [hydrolase activity]
Show all
 272 aa
31.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.