Expression of SPRYD3 in cancer - Summary - The Human Protein Atlas

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SPRYD3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SPRYD3
Gene description	SPRY domain containing 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues, abundant in neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA039426 , HPA039685
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039426	HPA039685

GENE INFORMATION
Gene name	SPRYD3 (HGNC Symbol)
Synonyms	FLJ14800
Description	SPRY domain containing 3 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53064316 - 53079420
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167778 (version 83.38)
Entrez gene	84926
UniProt	Q8NCJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCJ5
Antibodypedia	SPRYD3 antibodies

PROTEIN BROWSER

SPRYD3-001	SPRYD3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SPRYD3-001 ENSP00000301463 ENST00000301463	Q8NCJ5 [Direct mapping] SPRY domain-containing protein 3 A0A024RAX4 [Target identity:100%; Query identity:100%] SPRY domain containing 3, isoform CRA_b Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	442 aa 49.7 kDa	No	0
SPRYD3-003 ENSP00000449452 ENST00000547837	F8VWW7 [Direct mapping] SPRY domain-containing protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	479 aa 53.8 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.