Expression of IGFBP6 in cancer - Summary - The Human Protein Atlas

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IGFBP6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IGFBP6
Gene description	Insulin-like growth factor binding protein 6
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (BJ, HaCaT, U-87 MG)
HPA (normal tissue):	Tissue enhanced (adipose tissue)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Uncertain based on 1 antibody. HPA008005
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable).
Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA008005

GENE INFORMATION
Gene name	IGFBP6
Synonyms
Description	Insulin-like growth factor binding protein 6 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53097436 - 53102345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167779 (version 83.38)
Entrez gene	3489
UniProt	P24592 (UniProt - Evidence at protein level)
neXtProt	NX_P24592
Antibodypedia	IGFBP6 antibodies

PROTEIN BROWSER

IGFBP6-001	IGFBP6-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IGFBP6-001 ENSP00000301464 ENST00000301464	P24592 [Direct mapping] Insulin-like growth factor-binding protein 6 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0007165 [signal transduction] GO:0008285 [negative regulation of cell proliferation] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	240 aa 25.3 kDa	Yes	0
IGFBP6-004 ENSP00000448953 ENST00000548547	F8VYK9 [Direct mapping] Insulin-like growth factor-binding protein 6 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0005520 [insulin-like growth factor binding] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0031994 [insulin-like growth factor I binding] GO:0031995 [insulin-like growth factor II binding] GO:0043567 [regulation of insulin-like growth factor receptor signaling pathway] Show all	238 aa 25.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.