Expression of NDUFV1 in cancer - Summary - The Human Protein Atlas

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NDUFV1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NDUFV1
Gene description	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression with a granular pattern in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA045211
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045211

GENE INFORMATION
Gene name	NDUFV1 (HGNC Symbol)
Synonyms	CI-51K
Description	NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa (HGNC Symbol)
Entrez gene summary	The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in 10,000 live births. Mitochondrial complex I deficiency is linked to myopathies, encephalomyopathies, and neurodegenerative disorders such as Parkinson's disease and Leigh syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67606852 - 67612535
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167792 (version 83.38)
Entrez gene	4723
UniProt	P49821 (UniProt - Evidence at protein level)
neXtProt	NX_P49821
Antibodypedia	NDUFV1 antibodies

PROTEIN BROWSER

NDUFV1-001	NDUFV1-002	NDUFV1-003	NDUFV1-004	NDUFV1-005	NDUFV1-008	NDUFV1-009	NDUFV1-012	NDUFV1-013	NDUFV1-015	NDUFV1-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFV1-001 ENSP00000322450 ENST00000322776	P49821 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial E5KNH5 [Target identity:100%; Query identity:100%] Mitochondrial NADH dehydrogenase ubiquinone flavoprotein 1; NADH dehydrogenase (Ubiquinone) flavoprotein 1, 51kDa, isoform CRA_d Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003954 [NADH dehydrogenase activity] GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009060 [aerobic respiration] GO:0010181 [FMN binding] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051287 [NAD binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	464 aa 50.8 kDa	No	0
NDUFV1-002 ENSP00000395368 ENST00000415352	G3V0I5 [Direct mapping] NADH dehydrogenase (Ubiquinone) flavoprotein 1, 51kDa, isoform CRA_c; NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0010181 [FMN binding] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0051287 [NAD binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	457 aa 50.1 kDa	Yes	0
NDUFV1-003 ENSP00000436766 ENST00000529927	P49821 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003954 [NADH dehydrogenase activity] GO:0005743 [mitochondrial inner membrane] GO:0005747 [mitochondrial respiratory chain complex I] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0009060 [aerobic respiration] GO:0010181 [FMN binding] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0022904 [respiratory electron transport chain] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051287 [NAD binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	455 aa 49.9 kDa	No	0
NDUFV1-004 ENSP00000432015 ENST00000532303	B4DE93 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; cDNA FLJ57949, highly similar to NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC 1.6.5.3); cDNA, FLJ79021, highly similar to NADH-ubiquinone oxidoreductase 51 kDa subunit, mitochondrial (EC 1.6.5.3) Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0010181 [FMN binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	363 aa 39.5 kDa	No	0
NDUFV1-005 ENSP00000436906 ENST00000528328	E9PPS5 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		75 aa 8.3 kDa	No	0
NDUFV1-008 ENSP00000435202 ENST00000532244	E9PLC6 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0010181 [FMN binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	136 aa 14.8 kDa	No	0
NDUFV1-009 ENSP00000431751 ENST00000532343	E9PJL9 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		96 aa 10.5 kDa	No	0
NDUFV1-012 ENSP00000437267 ENST00000533075	E9PMX3 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19.7 kDa	No	0
NDUFV1-013 ENSP00000434438 ENST00000529867	E9PQP1 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		178 aa 19.8 kDa	No	0
NDUFV1-015 ENSP00000436936 ENST00000530638	E9PPR0 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 15.6 kDa	No	0
NDUFV1-017 ENSP00000434581 ENST00000528314	E9PPD6 [Direct mapping] NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		53 aa 5.7 kDa	No	0

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