Expression of NUDT8 in cancer - Summary - The Human Protein Atlas

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NUDT8

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NUDT8
Gene description	Nudix (nucleoside diphosphate linked moiety X)-type motif 8
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (RPMI-8226)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041252 , HPA041466
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041252	HPA041466

GENE INFORMATION
Gene name	NUDT8 (HGNC Symbol)
Synonyms	FLJ41567
Description	Nudix (nucleoside diphosphate linked moiety X)-type motif 8 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	67627938 - 67629930
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167799 (version 83.38)
Entrez gene	254552
UniProt	Q8WV74 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV74
Antibodypedia	NUDT8 antibodies

PROTEIN BROWSER

NUDT8-001	NUDT8-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUDT8-001 ENSP00000365883 ENST00000376693	Q8WV74 [Direct mapping] Nucleoside diphosphate-linked moiety X motif 8, mitochondrial Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	236 aa 25.4 kDa	No	0
NUDT8-002 ENSP00000301490 ENST00000301490	Q8WV74 [Direct mapping] Nucleoside diphosphate-linked moiety X motif 8, mitochondrial Show all	Phobius predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008152 [metabolic process] GO:0016787 [hydrolase activity] GO:0046872 [metal ion binding] Show all	140 aa 15.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.