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This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
P32119 [Direct mapping] Peroxiredoxin-2 V9HW12 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein Li 2a; Peroxiredoxin 2, isoform CRA_b
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Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000302 [response to reactive oxygen species] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0006979 [response to oxidative stress] GO:0008379 [thioredoxin peroxidase activity] GO:0010467 [gene expression] GO:0016209 [antioxidant activity] GO:0016491 [oxidoreductase activity] GO:0019430 [removal of superoxide radicals] GO:0034599 [cellular response to oxidative stress] GO:0042744 [hydrogen peroxide catabolic process] GO:0042981 [regulation of apoptotic process] GO:0043066 [negative regulation of apoptotic process] GO:0043524 [negative regulation of neuron apoptotic process] GO:0051920 [peroxiredoxin activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome]
