Fields »
ABOUT
HELP
BLOG
MIS12

GENERAL INFORMATION

Gene name

 MIS12

Gene description

 MIS12 kinetochore complex component

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA044482
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044482

GENE INFORMATION

Gene name

 MIS12 (HGNC Symbol)

Synonyms

 hMIS12, KNTC2AP, MGC2488, MTW1

Description

 MIS12 kinetochore complex component (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 p13.2

Chromosome location (bp)

 5486285 - 5490814

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167842 (version 83.38)

Entrez gene

 79003

UniProt

 Q9H081 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9H081

Antibodypedia

 MIS12 antibodies

PROTEIN BROWSER
MIS12-001
MIS12-002
MIS12-003
MIS12-004
MIS12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MIS12-001
ENSP00000370557
ENST00000381165
Q9H081 [Direct mapping]
Protein MIS12 homolog
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000444 [MIS12/MIND type complex]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
Show all
 205 aa
24.1 kDa 		No 0
MIS12-002
ENSP00000461252
ENST00000573759
Q9H081 [Direct mapping]
Protein MIS12 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000444 [MIS12/MIND type complex]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
Show all
 205 aa
24.1 kDa 		No 0
MIS12-003
ENSP00000461333
ENST00000576988
I3L4K6 [Direct mapping]
Protein MIS12 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0005634 [nucleus]
GO:0007049 [cell cycle]
GO:0007067 [mitotic nuclear division]
Show all
 125 aa
14.8 kDa 		No 0
MIS12-004
ENSP00000459366
ENST00000576570
I3L244 [Direct mapping]
Protein MIS12 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 24 aa
2.8 kDa 		No 0
MIS12-201
ENSP00000484532
ENST00000611091
Q9H081 [Direct mapping]
Protein MIS12 homolog
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000444 [MIS12/MIND type complex]
GO:0000775 [chromosome, centromeric region]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0007049 [cell cycle]
GO:0007059 [chromosome segregation]
GO:0007067 [mitotic nuclear division]
GO:0007264 [small GTPase mediated signal transduction]
GO:0051301 [cell division]
GO:0051382 [kinetochore assembly]
Show all
 205 aa
24.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.