Fields »
ABOUT
HELP
BLOG
CD300A

GENERAL INFORMATION

Gene name

 CD300A

Gene description

 CD300a molecule

Protein class

 CD markers
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1, NB-4, RPMI-8226)
HPA (normal tissue):Tissue enhanced (spleen)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression, high in immune cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA011645
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA011645

GENE INFORMATION

Gene name

 CD300A (HGNC Symbol)

Synonyms

 CMRF-35-H9, CMRF35H, IGSF12, IRC1, IRC2, Irp60

Description

 CD300a molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 74466416 - 74484796

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167851 (version 83.38)

Entrez gene

 11314

UniProt

 Q9UGN4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UGN4

Antibodypedia

 CD300A antibodies

PROTEIN BROWSER
CD300A-001
CD300A-002
CD300A-003
CD300A-005
CD300A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD300A-001
ENSP00000353259
ENST00000360141
Q9UGN4 [Direct mapping]
CMRF35-like molecule 8
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786 [phosphatidylserine binding]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0038023 [signaling receptor activity]
GO:0043305 [negative regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050776 [regulation of immune response]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
GO:0051134 [negative regulation of NK T cell activation]
GO:0060101 [negative regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:1902564 [negative regulation of neutrophil activation]
GO:1902567 [negative regulation of eosinophil activation]
GO:1902569 [negative regulation of activation of JAK2 kinase activity]
GO:2000417 [negative regulation of eosinophil migration]
Show all
 299 aa
33.2 kDa 		Yes 1
CD300A-002
ENSP00000308188
ENST00000310828
Q9UGN4 [Direct mapping]
CMRF35-like molecule 8
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786 [phosphatidylserine binding]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0038023 [signaling receptor activity]
GO:0043305 [negative regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050776 [regulation of immune response]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
GO:0051134 [negative regulation of NK T cell activation]
GO:0060101 [negative regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:1902564 [negative regulation of neutrophil activation]
GO:1902567 [negative regulation of eosinophil activation]
GO:1902569 [negative regulation of activation of JAK2 kinase activity]
GO:2000417 [negative regulation of eosinophil migration]
Show all
 186 aa
20.6 kDa 		Yes 1
CD300A-003
ENSP00000376401
ENST00000392625
Q9UGN4 [Direct mapping]
CMRF35-like molecule 8
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786 [phosphatidylserine binding]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0038023 [signaling receptor activity]
GO:0043305 [negative regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050776 [regulation of immune response]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
GO:0051134 [negative regulation of NK T cell activation]
GO:0060101 [negative regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:1902564 [negative regulation of neutrophil activation]
GO:1902567 [negative regulation of eosinophil activation]
GO:1902569 [negative regulation of activation of JAK2 kinase activity]
GO:2000417 [negative regulation of eosinophil migration]
Show all
 150 aa
16.5 kDa 		Yes 1
CD300A-005
ENSP00000354564
ENST00000361933
Q9UGN4 [Direct mapping]
CMRF35-like molecule 8
Show all
CD markers
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001786 [phosphatidylserine binding]
GO:0002376 [immune system process]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0008429 [phosphatidylethanolamine binding]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030889 [negative regulation of B cell proliferation]
GO:0032516 [positive regulation of phosphoprotein phosphatase activity]
GO:0033007 [negative regulation of mast cell activation involved in immune response]
GO:0038023 [signaling receptor activity]
GO:0043305 [negative regulation of mast cell degranulation]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0048147 [negative regulation of fibroblast proliferation]
GO:0050776 [regulation of immune response]
GO:0050856 [regulation of T cell receptor signaling pathway]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
GO:0051134 [negative regulation of NK T cell activation]
GO:0060101 [negative regulation of phagocytosis, engulfment]
GO:0070062 [extracellular exosome]
GO:1902564 [negative regulation of neutrophil activation]
GO:1902567 [negative regulation of eosinophil activation]
GO:1902569 [negative regulation of activation of JAK2 kinase activity]
GO:2000417 [negative regulation of eosinophil migration]
Show all
 103 aa
11.9 kDa 		Yes 0
CD300A-006
ENSP00000463189
ENST00000577511
J3QKQ4 [Direct mapping]
CMRF35-like molecule 8
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 169 aa
18.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.