Expression of TEKT1 in cancer - Summary

GENERAL INFORMATION
Gene name	TEKT1
Gene description	Tektin 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (endometrial cancer, glioma, lung cancer, ovarian cancer)
HPA (cell line):	Cell line enhanced (BJ hTERT+ SV40 Large T+ RasG12V, HUVEC TERT2)
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cilia and cytoplasmic expression in respiratory epithelial cells, fallopian tube and trophoblastic cells in placenta.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA044444 , HPA062285
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (endometrial cancer, glioma, lung cancer, ovarian cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA044444	HPA062285

GENE INFORMATION
Gene name	TEKT1
Synonyms
Description	Tektin 1 (HGNC Symbol)
Entrez gene summary	This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is predominantly expressed in the testis and in mouse, tektin 1 mRNA was localized to the spermatocytes and round spermatids in the seminiferous tubules, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	6789133 - 6831761
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167858 (version 83.38)
Entrez gene	83659
UniProt	Q969V4 (UniProt - Evidence at protein level)
neXtProt	NX_Q969V4
Antibodypedia	TEKT1 antibodies

PROTEIN BROWSER

TEKT1-001	TEKT1-004	TEKT1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TEKT1-001 ENSP00000341346 ENST00000338694	Q969V4 [Direct mapping] Tektin-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005874 [microtubule] GO:0005929 [cilium] GO:0015630 [microtubule cytoskeleton] Show all	418 aa 48.3 kDa	No	0
TEKT1-004 ENSP00000458518 ENST00000572291	I3L122 [Direct mapping] Tektin-1 Show all	Predicted intracellular proteins Show all		144 aa 15.8 kDa	No	0
TEKT1-005 ENSP00000460197 ENST00000571744	I3L357 [Direct mapping] Tektin-1 Show all	Predicted intracellular proteins Show all		64 aa 7.2 kDa	No	0