Expression of TMEM88 in cancer - Summary - The Human Protein Atlas

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TMEM88

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM88
Gene description	Transmembrane protein 88
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Group enriched (AN3-CA, HUVEC TERT2, NTERA-2)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA052991
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable) and colorectal cancer (unfavourable).
Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA052991

GENE INFORMATION
Gene name	TMEM88 (HGNC Symbol)
Synonyms	FLJ20025, MGC71744
Description	Transmembrane protein 88 (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	p13.1
Chromosome location (bp)	7855065 - 7856099
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167874 (version 83.38)
Entrez gene	92162
UniProt	Q6PEY1 (UniProt - Evidence at protein level)
neXtProt	NX_Q6PEY1
Antibodypedia	TMEM88 antibodies

PROTEIN BROWSER

TMEM88-001	TMEM88-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM88-001 ENSP00000301599 ENST00000301599	Q6PEY1 [Direct mapping] Transmembrane protein 88 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007275 [multicellular organismal development] GO:0016021 [integral component of membrane] GO:0016055 [Wnt signaling pathway] Show all	159 aa 17.3 kDa	No	2
TMEM88-002 ENSP00000459725 ENST00000574668	I3L2J3 [Direct mapping] Transmembrane protein 88 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	126 aa 13.3 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.