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EVPL

GENERAL INFORMATION

Gene name

 EVPL

Gene description

 Envoplakin

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (HaCaT, RT4, T-47d)
HPA (normal tissue):Group enriched (esophagus, skin)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression mainly in squamous epithelia.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA053969 , CAB002220
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053969
CAB002220

GENE INFORMATION

Gene name

 EVPL (HGNC Symbol)

Synonyms

 EVPK

Description

 Envoplakin (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q25.1

Chromosome location (bp)

 76004502 - 76027452

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167880 (version 83.38)

Entrez gene

 2125

UniProt

 Q92817 (UniProt - Evidence at protein level)

neXtProt

 NX_Q92817

Antibodypedia

 EVPL antibodies

PROTEIN BROWSER
EVPL-001
EVPL-002
EVPL-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EVPL-001
ENSP00000301607
ENST00000301607
Q92817 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0018149 [peptide cross-linking]
GO:0019215 [intermediate filament binding]
GO:0030057 [desmosome]
GO:0030216 [keratinocyte differentiation]
GO:0030674 [protein binding, bridging]
GO:0031424 [keratinization]
GO:0070062 [extracellular exosome]
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 2033 aa
231.6 kDa 		No 0
EVPL-002
ENSP00000465630
ENST00000586740
K7EKI0 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0019215 [intermediate filament binding]
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 2055 aa
233.8 kDa 		No 0
EVPL-005
ENSP00000467717
ENST00000589231
K7EQ87 [Direct mapping]
Envoplakin
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001533 [cornified envelope]
GO:0005198 [structural molecule activity]
GO:0005856 [cytoskeleton]
GO:0008544 [epidermis development]
GO:0019215 [intermediate filament binding]
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 112 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.