Expression of TK1 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TK1
Gene description	Thymidine kinase 1, soluble
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells, squamous epithelia and glandular cells of the female genital system, and in the gastrointestinal tract.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. CAB004683
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB004683

GENE INFORMATION
Gene name	TK1
Synonyms
Description	Thymidine kinase 1, soluble (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q25.3
Chromosome location (bp)	78174075 - 78187233
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167900 (version 83.38)
Entrez gene	7083
UniProt	P04183 (UniProt - Evidence at protein level)
neXtProt	NX_P04183
Antibodypedia	TK1 antibodies

PROTEIN BROWSER

TK1-001	TK1-002	TK1-004	TK1-005	TK1-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TK1-001 ENSP00000301634 ENST00000301634	P04183 [Direct mapping] Thymidine kinase, cytosolic Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001889 [liver development] GO:0004797 [thymidine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005829 [cytosol] GO:0006139 [nucleobase-containing compound metabolic process] GO:0006206 [pyrimidine nucleobase metabolic process] GO:0008270 [zinc ion binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0009165 [nucleotide biosynthetic process] GO:0009636 [response to toxic substance] GO:0014856 [skeletal muscle cell proliferation] GO:0016310 [phosphorylation] GO:0019206 [nucleoside kinase activity] GO:0031667 [response to nutrient levels] GO:0042802 [identical protein binding] GO:0043097 [pyrimidine nucleoside salvage] GO:0044281 [small molecule metabolic process] GO:0046104 [thymidine metabolic process] GO:0046688 [response to copper ion] GO:0048565 [digestive tract development] GO:0051289 [protein homotetramerization] GO:0051414 [response to cortisol] GO:0055086 [nucleobase-containing small molecule metabolic process] GO:0060138 [fetal process involved in parturition] GO:0071897 [DNA biosynthetic process] Show all	234 aa 25.5 kDa	No	0
TK1-002 ENSP00000468425 ENST00000588734	K7ERV3 [Direct mapping] Thymidine kinase Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0016310 [phosphorylation] GO:0071897 [DNA biosynthetic process] Show all	267 aa 28.6 kDa	No	0
TK1-004 ENSP00000468278 ENST00000586613	K7ERJ1 [Direct mapping] Thymidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0016310 [phosphorylation] GO:0071897 [DNA biosynthetic process] Show all	187 aa 20.5 kDa	No	0
TK1-005 ENSP00000467121 ENST00000590430	K7ENW5 [Direct mapping] Thymidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0016310 [phosphorylation] GO:0071897 [DNA biosynthetic process] Show all	87 aa 9.9 kDa	No	0
TK1-006 ENSP00000468556 ENST00000590862	K7ES52 [Direct mapping] Thymidine kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004797 [thymidine kinase activity] GO:0005524 [ATP binding] GO:0009157 [deoxyribonucleoside monophosphate biosynthetic process] GO:0016310 [phosphorylation] GO:0071897 [DNA biosynthetic process] Show all	180 aa 19.8 kDa	No	0