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CYP7A1

GENERAL INFORMATION

Gene name

 CYP7A1

Gene description

 Cytochrome P450, family 7, subfamily A, polypeptide 1

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (liver cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (liver)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 CYP7A1 (HGNC Symbol)

Synonyms

 CYP7

Description

 Cytochrome P450, family 7, subfamily A, polypeptide 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010]

Chromosome

 8

Cytoband

 q12.1

Chromosome location (bp)

 58490178 - 58500236

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167910 (version 83.38)

Entrez gene

 1581

UniProt

 P22680 (UniProt - Evidence at protein level)

neXtProt

 NX_P22680

Antibodypedia

 CYP7A1 antibodies

PROTEIN BROWSER
CYP7A1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CYP7A1-001
ENSP00000301645
ENST00000301645
P22680 [Direct mapping]
Cholesterol 7-alpha-monooxygenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0005506 [iron ion binding]
GO:0005789 [endoplasmic reticulum membrane]
GO:0006699 [bile acid biosynthetic process]
GO:0006707 [cholesterol catabolic process]
GO:0006805 [xenobiotic metabolic process]
GO:0008123 [cholesterol 7-alpha-monooxygenase activity]
GO:0008206 [bile acid metabolic process]
GO:0016125 [sterol metabolic process]
GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen]
GO:0020037 [heme binding]
GO:0042632 [cholesterol homeostasis]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0044255 [cellular lipid metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0071333 [cellular response to glucose stimulus]
GO:0071397 [cellular response to cholesterol]
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 504 aa
57.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.