Expression of GSDMA in cancer - Summary - The Human Protein Atlas

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GSDMA

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GSDMA
Gene description	Gasdermin A
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (hTCEpi)
HPA (normal tissue):	Tissue enriched (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in sebaceous glands and epidermal cells of skin.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA023313 , HPA064826
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023313	HPA064826

GENE INFORMATION
Gene name	GSDMA (HGNC Symbol)
Synonyms	FLJ39120, GSDM, GSDM1
Description	Gasdermin A (HGNC Symbol)
Entrez gene summary
Chromosome	17
Cytoband	q21.1
Chromosome location (bp)	39962973 - 39977766
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167914 (version 83.38)
Entrez gene	284110
UniProt	Q96QA5 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QA5
Antibodypedia	GSDMA antibodies

PROTEIN BROWSER

GSDMA-001	GSDMA-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GSDMA-001 ENSP00000301659 ENST00000301659	Q96QA5 [Direct mapping] Gasdermin-A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0048471 [perinuclear region of cytoplasm] Show all	445 aa 49.4 kDa	No	0
GSDMA-002 ENSP00000461985 ENST00000577447	J3KRG2 [Direct mapping] Gasdermin-A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 17.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.