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SOST

GENERAL INFORMATION

Gene name

 SOST

Gene description

 Sclerostin

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (head and neck cancer, lung cancer, urothelial cancer)
HPA (cell line):Cell line enriched (HaCaT)
HPA (normal tissue):Tissue enriched (kidney)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissue types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB025660
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (head and neck cancer, lung cancer, urothelial cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025660

GENE INFORMATION

Gene name

 SOST (HGNC Symbol)

Synonyms

 VBCH

Description

 Sclerostin (HGNC Symbol)

Entrez gene summary

 Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease. [provided by RefSeq, Jul 2008]

Chromosome

 17

Cytoband

 q21.31

Chromosome location (bp)

 43753731 - 43758788

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000167941 (version 83.38)

Entrez gene

 50964

UniProt

 Q9BQB4 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQB4

Antibodypedia

 SOST antibodies

PROTEIN BROWSER
SOST-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SOST-001
ENSP00000301691
ENST00000301691
Q9BQB4 [Direct mapping]
Sclerostin
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
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GO:0001503 [ossification]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005794 [Golgi apparatus]
GO:0008134 [transcription factor binding]
GO:0008201 [heparin binding]
GO:0009612 [response to mechanical stimulus]
GO:0016055 [Wnt signaling pathway]
GO:0030178 [negative regulation of Wnt signaling pathway]
GO:0030279 [negative regulation of ossification]
GO:0030514 [negative regulation of BMP signaling pathway]
GO:0031012 [extracellular matrix]
GO:0031333 [negative regulation of protein complex assembly]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071374 [cellular response to parathyroid hormone stimulus]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:2000054 [negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification]
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 213 aa
24 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.