Tissue expression of E4F1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	E4F1
Gene description	E4F transcription factor 1
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	E4F1 (HGNC Symbol)
Synonyms	E4F
Description	E4F transcription factor 1 (HGNC Symbol)
Entrez gene summary	The zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence. Alternative splicing results in multiple transcripts encoding different proteins. [provided by RefSeq, Jan 2014]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2223566 - 2235742
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167967 (version 83.38)
Entrez gene	1877
UniProt	Q66K89 (UniProt - Evidence at protein level)
neXtProt	NX_Q66K89
Antibodypedia	E4F1 antibodies

PROTEIN BROWSER

E4F1-001	E4F1-002	E4F1-004	E4F1-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
E4F1-001 ENSP00000301727 ENST00000301727	Q66K89 [Direct mapping] Transcription factor E4F1 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding] GO:0001227 [transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003713 [transcription coactivator activity] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005819 [spindle] GO:0006260 [DNA replication] GO:0006351 [transcription, DNA-templated] GO:0007067 [mitotic nuclear division] GO:0008283 [cell proliferation] GO:0009794 [regulation of mitotic cell cycle, embryonic] GO:0010564 [regulation of cell cycle process] GO:0016032 [viral process] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0035497 [cAMP response element binding] GO:0040008 [regulation of growth] GO:0046872 [metal ion binding] GO:0051301 [cell division] GO:0071850 [mitotic cell cycle arrest] Show all	784 aa 83.5 kDa	No	0
E4F1-002 ENSP00000456760 ENST00000565090	H3BSL4 [Direct mapping] Transcription factor E4F1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005654 [nucleoplasm] GO:0046872 [metal ion binding] Show all	607 aa 64 kDa	No	0
E4F1-004 ENSP00000457672 ENST00000564139	H3BUJ7 [Direct mapping] Transcription factor E4F1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0005515 [protein binding] GO:0046872 [metal ion binding] Show all	654 aa 70.4 kDa	No	0
E4F1-008 ENSP00000454652 ENST00000565413	H3BN24 [Direct mapping] Transcription factor E4F1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0046872 [metal ion binding] Show all	272 aa 29.1 kDa	No	0