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Gene name

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Reliability

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Cancer

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Detectable

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Detectable

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ABCA3
  • TISSUE

  • CELL

  • PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

ABCA3

Gene description

ATP-binding cassette, sub-family A (ABC1), member 3

Protein class

Disease related genes
Plasma proteins
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

Membrane

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (lung)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic expression in pneumocytes in lung. Also weaker cytoplasmic expression in several tissues as well.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

Approved based on 1 antibody.
HPA007884
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Lung

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (lung)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

ABCA3 (HGNC Symbol)

Synonyms

ABC-C, ABC3, EST111653, LBM180

Description

ATP-binding cassette, sub-family A (ABC1), member 3 (HGNC Symbol)

Entrez gene summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]

Chromosome

16

Cytoband

p13.3

Chromosome location (bp)

2275881 - 2340746

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000167972 (version 83.38)

Entrez gene

21

UniProt

Q99758 (UniProt - Evidence at protein level)

neXtProt

NX_Q99758

Antibodypedia

ABCA3 antibodies

PROTEIN BROWSER

ABCA3-001
ABCA3-003
ABCA3-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ABCA3-001
ENSP00000301732
ENST00000301732
Q99758 [Direct mapping]
ATP-binding cassette sub-family A member 3
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006869 [lipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044267 [cellular protein metabolic process]
GO:0051384 [response to glucocorticoid]
GO:0055085 [transmembrane transport]
GO:0097208 [alveolar lamellar body]
GO:0097232 [lamellar body membrane]
GO:0097233 [alveolar lamellar body membrane]
Show all
1704 aa
191.4 kDa
No >9
ABCA3-003
ENSP00000371818
ENST00000382381
H0Y3H2 [Direct mapping]
ATP-binding cassette sub-family A member 3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0006869 [lipid transport]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016887 [ATPase activity]
GO:0055085 [transmembrane transport]
Show all
1646 aa
184.9 kDa
No >9
ABCA3-004
ENSP00000454397
ENST00000567910
Q99758 [Direct mapping]
ATP-binding cassette sub-family A member 3
Show all
Transporters
   Primary Active Transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0006810 [transport]
GO:0006869 [lipid transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0042493 [response to drug]
GO:0042626 [ATPase activity, coupled to transmembrane movement of substances]
GO:0044267 [cellular protein metabolic process]
GO:0055085 [transmembrane transport]
GO:0097208 [alveolar lamellar body]
GO:0097232 [lamellar body membrane]
Show all
209 aa
24 kDa
No 1

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