Tissue expression of ABCA3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ABCA3
Gene description	ATP-binding cassette, sub-family A (ABC1), member 3
Protein class	Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (lung)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

High cytoplasmic expression in pneumocytes in lung. Also weaker cytoplasmic expression in several tissues as well.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA007884
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	ABCA3 (HGNC Symbol)
Synonyms	ABC-C, ABC3, EST111653, LBM180
Description	ATP-binding cassette, sub-family A (ABC1), member 3 (HGNC Symbol)
Entrez gene summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	2275881 - 2340746
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167972 (version 83.38)
Entrez gene	21
UniProt	Q99758 (UniProt - Evidence at protein level)
neXtProt	NX_Q99758
Antibodypedia	ABCA3 antibodies

PROTEIN BROWSER

ABCA3-001	ABCA3-003	ABCA3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ABCA3-001 ENSP00000301732 ENST00000301732	Q99758 [Direct mapping] ATP-binding cassette sub-family A member 3 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006869 [lipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044267 [cellular protein metabolic process] GO:0051384 [response to glucocorticoid] GO:0055085 [transmembrane transport] GO:0097208 [alveolar lamellar body] GO:0097232 [lamellar body membrane] GO:0097233 [alveolar lamellar body membrane] Show all	1704 aa 191.4 kDa	No	>9
ABCA3-003 ENSP00000371818 ENST00000382381	H0Y3H2 [Direct mapping] ATP-binding cassette sub-family A member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0006869 [lipid transport] GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016887 [ATPase activity] GO:0055085 [transmembrane transport] Show all	1646 aa 184.9 kDa	No	>9
ABCA3-004 ENSP00000454397 ENST00000567910	Q99758 [Direct mapping] ATP-binding cassette sub-family A member 3 Show all	Transporters Primary Active Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005524 [ATP binding] GO:0005615 [extracellular space] GO:0005886 [plasma membrane] GO:0006810 [transport] GO:0006869 [lipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0042493 [response to drug] GO:0042626 [ATPase activity, coupled to transmembrane movement of substances] GO:0044267 [cellular protein metabolic process] GO:0055085 [transmembrane transport] GO:0097208 [alveolar lamellar body] GO:0097232 [lamellar body membrane] Show all	209 aa 24 kDa	No	1