Tissue expression of SDHAF2 - Summary - The Human Protein Atlas

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SDHAF2

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TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	SDHAF2
Gene description	Succinate dehydrogenase complex assembly factor 2
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Mixed
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous granular cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 2 antibodies. HPA039464 , HPA039732
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	SDHAF2 (HGNC Symbol)
Synonyms	C11orf79, FLJ20487, PGL2, SDH5
Description	Succinate dehydrogenase complex assembly factor 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.[provided by RefSeq, Jul 2010]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61430042 - 61447529
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000167985 (version 83.38)
Entrez gene	54949
UniProt	Q9NX18 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NX18
Antibodypedia	SDHAF2 antibodies

PROTEIN BROWSER

SDHAF2-001	SDHAF2-005	SDHAF2-006	SDHAF2-007	SDHAF2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDHAF2-001 ENSP00000301761 ENST00000301761	Q9NX18 [Direct mapping] Succinate dehydrogenase assembly factor 2, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations Disease related genes Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0005759 [mitochondrial matrix] GO:0006121 [mitochondrial electron transport, succinate to ubiquinone] GO:0006470 [protein dephosphorylation] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0018293 [protein-FAD linkage] GO:0090090 [negative regulation of canonical Wnt signaling pathway] Show all	166 aa 19.6 kDa	Yes	0
SDHAF2-005 ENSP00000471030 ENST00000534878	M0R060 [Direct mapping] Succinate dehydrogenase assembly factor 2, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations Show all		141 aa 16.5 kDa	No	0
SDHAF2-006 ENSP00000469670 ENST00000542074	M0QY91 [Direct mapping] Succinate dehydrogenase assembly factor 2, mitochondrial Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations Show all		28 aa 3.2 kDa	No	0
SDHAF2-007 ENSP00000443660 ENST00000543265	F5H8E2 [Direct mapping] Succinate dehydrogenase assembly factor 2, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations Show all		88 aa 10.1 kDa	No	0
SDHAF2-010 ENSP00000469951 ENST00000537782	M0QYN2 [Direct mapping] Succinate dehydrogenase assembly factor 2, mitochondrial Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Germline Mutations Show all		133 aa 15.3 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.