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RPSA

GENERAL INFORMATION

Gene name

 RPSA

Gene description

 Ribosomal protein SA

Protein class

 Plasma proteins
Predicted intracellular proteins
Ribosomal proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB009561
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009561

GENE INFORMATION

Gene name

 RPSA (HGNC Symbol)

Synonyms

 37LRP, LAMR1, LRP, p40, SA

Description

 Ribosomal protein SA (HGNC Symbol)

Entrez gene summary

 Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p22.1

Chromosome location (bp)

 39406689 - 39412542

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168028 (version 83.38)

Entrez gene

 3921

UniProt

 P08865 (UniProt - Evidence at protein level)

neXtProt

 NX_P08865

Antibodypedia

 RPSA antibodies

PROTEIN BROWSER
RPSA-001
RPSA-002
RPSA-008
RPSA-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RPSA-001
ENSP00000346067
ENST00000301821
P08865 [Direct mapping]
40S ribosomal protein SA
A0A024R2P0 [Target identity:100%; Query identity:100%]
40S ribosomal protein SA
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Ribosomal proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0001618 [virus receptor activity]
GO:0003735 [structural constituent of ribosome]
GO:0005055 [laminin receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005886 [plasma membrane]
GO:0006407 [rRNA export from nucleus]
GO:0006412 [translation]
GO:0006413 [translational initiation]
GO:0006414 [translational elongation]
GO:0006415 [translational termination]
GO:0006614 [SRP-dependent cotranslational protein targeting to membrane]
GO:0007155 [cell adhesion]
GO:0010467 [gene expression]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016032 [viral process]
GO:0019058 [viral life cycle]
GO:0019083 [viral transcription]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030686 [90S preribosome]
GO:0043022 [ribosome binding]
GO:0043236 [laminin binding]
GO:0044267 [cellular protein metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0046718 [viral entry into host cell]
GO:0070062 [extracellular exosome]
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 295 aa
32.9 kDa 		No 0
RPSA-002
ENSP00000389351
ENST00000443003
A0A0C4DG17 [Direct mapping]
40S ribosomal protein SA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000028 [ribosomal small subunit assembly]
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005055 [laminin receptor activity]
GO:0005604 [basement membrane]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005840 [ribosome]
GO:0005886 [plasma membrane]
GO:0006407 [rRNA export from nucleus]
GO:0006412 [translation]
GO:0015935 [small ribosomal subunit]
GO:0016020 [membrane]
GO:0016337 [single organismal cell-cell adhesion]
GO:0022627 [cytosolic small ribosomal subunit]
GO:0030686 [90S preribosome]
GO:0030855 [epithelial cell differentiation]
GO:0031012 [extracellular matrix]
GO:0043025 [neuronal cell body]
GO:0043236 [laminin binding]
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 300 aa
33.3 kDa 		No 0
RPSA-008
ENSP00000410848
ENST00000458478
C9J9K3 [Direct mapping]
40S ribosomal protein SA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006407 [rRNA export from nucleus]
GO:0006412 [translation]
GO:0015935 [small ribosomal subunit]
GO:0030686 [90S preribosome]
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 264 aa
29.5 kDa 		No 0
RPSA-009
ENSP00000396716
ENST00000444512
F8WD59 [Direct mapping]
40S ribosomal protein SA
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000028 [ribosomal small subunit assembly]
GO:0000447 [endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0000461 [endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)]
GO:0003735 [structural constituent of ribosome]
GO:0005622 [intracellular]
GO:0005840 [ribosome]
GO:0006407 [rRNA export from nucleus]
GO:0006412 [translation]
GO:0015935 [small ribosomal subunit]
GO:0030686 [90S preribosome]
Show all
 116 aa
12.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.