Expression of NAALADL1 in cancer - Summary

GENERAL INFORMATION
Gene name	NAALADL1
Gene description	N-acetylated alpha-linked acidic dipeptidase-like 1
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (ASC TERT1, SCLC-21H)
HPA (normal tissue):	Tissue enriched (small intestine)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues, most abundant in small intestine.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA047123
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047123

GENE INFORMATION
Gene name	NAALADL1
Synonyms
Description	N-acetylated alpha-linked acidic dipeptidase-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q13.1
Chromosome location (bp)	65044818 - 65058549
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168060 (version 83.38)
Entrez gene	10004
UniProt	Q9UQQ1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UQQ1
Antibodypedia	NAALADL1 antibodies

PROTEIN BROWSER

NAALADL1-001	NAALADL1-004	NAALADL1-008	NAALADL1-011	NAALADL1-012	NAALADL1-014	NAALADL1-015	NAALADL1-016	NAALADL1-017	NAALADL1-020	NAALADL1-021	NAALADL1-022	NAALADL1-023	NAALADL1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NAALADL1-001 ENSP00000351484 ENST00000358658	Q9UQQ1 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016805 [dipeptidase activity] GO:0046872 [metal ion binding] Show all	740 aa 80.6 kDa	No	0
NAALADL1-004 ENSP00000431513 ENST00000528884	E9PKR0 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		26 aa 3.3 kDa	No	0
NAALADL1-008 ENSP00000433892 ENST00000533340	E9PIU1 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		27 aa 3.4 kDa	No	0
NAALADL1-011 ENSP00000434233 ENST00000530139	E9PRC7 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.1 kDa	No	0
NAALADL1-012 ENSP00000433538 ENST00000526516	E9PKG8 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		77 aa 8.6 kDa	No	0
NAALADL1-014 ENSP00000435267 ENST00000532802	E9PKW7 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.3 kDa	No	0
NAALADL1-015 ENSP00000431977 ENST00000526799	E9PII9 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		87 aa 9.6 kDa	No	0
NAALADL1-016 ENSP00000435549 ENST00000533842	E9PJQ1 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		35 aa 4.3 kDa	No	0
NAALADL1-017 ENSP00000434225 ENST00000533753	H0YDS5 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.9 kDa	No	0
NAALADL1-020 ENSP00000344244 ENST00000340252	Q9UQQ1 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016805 [dipeptidase activity] GO:0046872 [metal ion binding] Show all	791 aa 85.8 kDa	No	0
NAALADL1-021 ENSP00000347955 ENST00000355721	Q9UQQ1 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Enzymes ENZYME proteins Hydrolases Peptidases Metallopeptidases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004180 [carboxypeptidase activity] GO:0006508 [proteolysis] GO:0008233 [peptidase activity] GO:0008237 [metallopeptidase activity] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0016805 [dipeptidase activity] GO:0046872 [metal ion binding] Show all	699 aa 76.2 kDa	No	0
NAALADL1-022 ENSP00000349045 ENST00000356632	C9JFW8 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		705 aa 76.9 kDa	No	0
NAALADL1-023 ENSP00000431322 ENST00000530995	E9PLR8 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.9 kDa	No	0
NAALADL1-201 ENSP00000340111 ENST00000339885	C9JX16 [Direct mapping] N-acetylated-alpha-linked acidic dipeptidase-like protein Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		739 aa 80.5 kDa	No	0