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PBK

GENERAL INFORMATION

Gene name

 PBK

Gene description

 PDZ binding kinase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 High nuclear expression in spermatocytes in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA005753 , HPA050656
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA005753
HPA050656

GENE INFORMATION

Gene name

 PBK (HGNC Symbol)

Synonyms

 CT84, FLJ14385, Nori-3, SPK, TOPK

Description

 PDZ binding kinase (HGNC Symbol)

Entrez gene summary

 This gene encodes a serine/threonine protein kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family. Evidence suggests that mitotic phosphorylation is required for its catalytic activity. The encoded protein may be involved in the activation of lymphoid cells and support testicular functions, with a suggested role in the process of spermatogenesis. Overexpression of this gene has been implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 8

Cytoband

 p21.1

Chromosome location (bp)

 27809620 - 27838095

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168078 (version 83.38)

Entrez gene

 55872

UniProt

 Q96KB5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96KB5

Antibodypedia

 PBK antibodies

PROTEIN BROWSER
PBK-001
PBK-002
PBK-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PBK-001
ENSP00000301905
ENST00000301905
Q96KB5 [Direct mapping]
Lymphokine-activated killer T-cell-originated protein kinase
V9HWH0 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 164
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
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 322 aa
36.1 kDa 		No 0
PBK-002
ENSP00000428489
ENST00000522944
Q96KB5 [Direct mapping]
Lymphokine-activated killer T-cell-originated protein kinase
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0001933 [negative regulation of protein phosphorylation]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005575 [cellular_component]
GO:0005634 [nucleus]
GO:0006468 [protein phosphorylation]
GO:0007067 [mitotic nuclear division]
GO:0032435 [negative regulation of proteasomal ubiquitin-dependent protein catabolic process]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034644 [cellular response to UV]
GO:0050728 [negative regulation of inflammatory response]
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 333 aa
37.2 kDa 		No 0
PBK-005
ENSP00000427892
ENST00000521226
E5RFX4 [Direct mapping]
Lymphokine-activated killer T-cell-originated protein kinase
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 151 aa
17.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.