Expression of FAM83B in cancer - Summary

GENERAL INFORMATION
Gene name	FAM83B
Gene description	Family with sequence similarity 83, member B
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (head and neck cancer)
HPA (cell line):	Cell line enhanced (A-431, HaCaT, hTCEpi, RT4)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several different tissue types, most abundant in squamous epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA031464 , HPA031465
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (unfavourable), lung cancer (unfavourable) and pancreatic cancer (unfavourable).
Urothelial cancer p<0.001 Lung cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA031464	HPA031465

GENE INFORMATION
Gene name	FAM83B (HGNC Symbol)
Synonyms	C6orf143, FLJ30642
Description	Family with sequence similarity 83, member B (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	p12.1
Chromosome location (bp)	54846771 - 54942022
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168143 (version 83.38)
Entrez gene	222584
UniProt	Q5T0W9 (UniProt - Evidence at protein level)
neXtProt	NX_Q5T0W9
Antibodypedia	FAM83B antibodies

PROTEIN BROWSER

FAM83B-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM83B-001 ENSP00000304078 ENST00000306858	Q5T0W9 [Direct mapping] Protein FAM83B Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005154 [epidermal growth factor receptor binding] GO:0005737 [cytoplasm] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0008283 [cell proliferation] GO:0016020 [membrane] GO:0019901 [protein kinase binding] GO:0036312 [phosphatidylinositol 3-kinase regulatory subunit binding] GO:0036313 [phosphatidylinositol 3-kinase catalytic subunit binding] Show all	1011 aa 114.8 kDa	No	0