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HIST3H3

GENERAL INFORMATION

Gene name

 HIST3H3

Gene description

 Histone cluster 3, H3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Not detected
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Correlation with RNA expression data cannot be evaluated due to technical limitations (poly-A tail missing).

Reliability score

 Supported based on 3 antibodies.
HPA042570 , CAB001386 , CAB003812
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042570
CAB001386
CAB003812

GENE INFORMATION

Gene name

 HIST3H3 (HGNC Symbol)

Synonyms

 H3.4, H3/g, H3FT, H3t

Description

 Histone cluster 3, H3 (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is located separately from the other H3 genes that are in the histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]

Chromosome

 1

Cytoband

 q42.13

Chromosome location (bp)

 228424845 - 228425325

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168148 (version 83.38)

Entrez gene

 8290

UniProt

 Q16695 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16695

Antibodypedia

 HIST3H3 antibodies

PROTEIN BROWSER
HIST3H3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST3H3-001
ENSP00000355657
ENST00000366696
Q16695 [Direct mapping]
Histone H3.1t
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000723 [telomere maintenance]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000786 [nucleosome]
GO:0000788 [nuclear nucleosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006303 [double-strand break repair via nonhomologous end joining]
GO:0006334 [nucleosome assembly]
GO:0032460 [negative regulation of protein oligomerization]
GO:0042393 [histone binding]
GO:0046982 [protein heterodimerization activity]
GO:0051290 [protein heterotetramerization]
GO:0070062 [extracellular exosome]
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 136 aa
15.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.