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RBPJ

GENERAL INFORMATION

Gene name

 RBPJ

Gene description

 Recombination signal binding protein for immunoglobulin kappa J region

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 22
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 RBPJ (HGNC Symbol)

Synonyms

 CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH

Description

 Recombination signal binding protein for immunoglobulin kappa J region (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase proteins to Notch signaling pathway genes. Several transcript variants encoding different isoforms have been found for this gene, and several pseudogenes of this gene exist on chromosome 9. [provided by RefSeq, Oct 2013]

Chromosome

 4

Cytoband

 p15.2

Chromosome location (bp)

 26163455 - 26435131

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168214 (version 83.38)

Entrez gene

 3516

UniProt

 Q06330 (UniProt - Evidence at protein level)

neXtProt

 NX_Q06330

Antibodypedia

 RBPJ antibodies

PROTEIN BROWSER
«
RBPJ-001
RBPJ-002
RBPJ-003
RBPJ-004
RBPJ-005
RBPJ-006
RBPJ-007
RBPJ-010
RBPJ-011
RBPJ-012
RBPJ-013
RBPJ-014
RBPJ-015
RBPJ-016
RBPJ-017
RBPJ-018
RBPJ-020
RBPJ-026
RBPJ-029
RBPJ-030
RBPJ-201
RBPJ-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBPJ-001
ENSP00000305815
ENST00000345843
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 485 aa
54.1 kDa 		No 0
RBPJ-002
ENSP00000354528
ENST00000361572
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 500 aa
55.6 kDa 		No 0
RBPJ-003
ENSP00000340124
ENST00000342320
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0
RBPJ-004
ENSP00000424789
ENST00000512351
D6RAT2 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 94 aa
10.9 kDa 		No 0
RBPJ-005
ENSP00000423644
ENST00000512671
D6R946 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 178 aa
20.2 kDa 		No 0
RBPJ-006
ENSP00000426872
ENST00000505958
D6RE93 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 28 aa
3.5 kDa 		No 0
RBPJ-007
ENSP00000423907
ENST00000507561
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 465 aa
51.9 kDa 		No 0
RBPJ-010
ENSP00000423703
ENST00000504907
D6R927 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 382 aa
43.5 kDa 		No 0
RBPJ-011
ENSP00000425750
ENST00000506956
D6RIZ8 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 97 aa
11.3 kDa 		No 0
RBPJ-012
ENSP00000424989
ENST00000514807
D6REP3 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 48 aa
5.7 kDa 		No 0
RBPJ-013
ENSP00000424804
ENST00000509158
D6RF98 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 49 aa
5.8 kDa 		No 0
RBPJ-014
ENSP00000425061
ENST00000514730
D6REC2 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 113 aa
13.1 kDa 		No 0
RBPJ-015
ENSP00000422617
ENST00000507574
D6RBQ8 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 157 aa
17.9 kDa 		No 0
RBPJ-016
ENSP00000423575
ENST00000514675
D6R9K5 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 110 aa
12.8 kDa 		No 0
RBPJ-017
ENSP00000423406
ENST00000515573
D6RA45 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 189 aa
21.5 kDa 		No 0
RBPJ-018
ENSP00000422838
ENST00000511546
D6R9X3 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 107 aa
12.4 kDa 		No 0
RBPJ-020
ENSP00000424459
ENST00000504938
D6RB37 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 143 aa
16.4 kDa 		No 0
RBPJ-026
ENSP00000421804
ENST00000504423
H0Y8R3 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 135 aa
15.4 kDa 		No 0
RBPJ-029
ENSP00000427170
ENST00000510778
D6RCM1 [Direct mapping]
Recombining-binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
Show all
 230 aa
26.4 kDa 		No 0
RBPJ-030
ENSP00000339699
ENST00000348160
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 487 aa
54.3 kDa 		No 0
RBPJ-201
ENSP00000345206
ENST00000342295
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0001974 [blood vessel remodeling]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003139 [secondary heart field specification]
GO:0003151 [outflow tract morphogenesis]
GO:0003157 [endocardium development]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006959 [humoral immune response]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0007507 [heart development]
GO:0008134 [transcription factor binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0009912 [auditory receptor cell fate commitment]
GO:0009957 [epidermal cell fate specification]
GO:0010467 [gene expression]
GO:0010468 [regulation of gene expression]
GO:0010628 [positive regulation of gene expression]
GO:0021983 [pituitary gland development]
GO:0030097 [hemopoiesis]
GO:0030182 [neuron differentiation]
GO:0030183 [B cell differentiation]
GO:0030216 [keratinocyte differentiation]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035019 [somatic stem cell population maintenance]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0042127 [regulation of cell proliferation]
GO:0042742 [defense response to bacterium]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045596 [negative regulation of cell differentiation]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0047485 [protein N-terminus binding]
GO:0048505 [regulation of timing of cell differentiation]
GO:0048733 [sebaceous gland development]
GO:0048820 [hair follicle maturation]
GO:0048844 [artery morphogenesis]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060486 [Clara cell differentiation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0060844 [arterial endothelial cell fate commitment]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0072602 [interleukin-4 secretion]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:1901297 [positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 500 aa
55.6 kDa 		No 0
RBPJ-202
ENSP00000347659
ENST00000355476
Q06330 [Direct mapping]
Recombining binding protein suppressor of hairless
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000150 [recombinase activity]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001103 [RNA polymerase II repressing transcription factor binding]
GO:0001525 [angiogenesis]
GO:0001837 [epithelial to mesenchymal transition]
GO:0002193 [MAML1-RBP-Jkappa- ICN1 complex]
GO:0003151 [outflow tract morphogenesis]
GO:0003160 [endocardium morphogenesis]
GO:0003198 [epithelial to mesenchymal transition involved in endocardial cushion formation]
GO:0003214 [cardiac left ventricle morphogenesis]
GO:0003222 [ventricular trabecula myocardium morphogenesis]
GO:0003256 [regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006310 [DNA recombination]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007219 [Notch signaling pathway]
GO:0007221 [positive regulation of transcription of Notch receptor target]
GO:0008134 [transcription factor binding]
GO:0010467 [gene expression]
GO:0030279 [negative regulation of ossification]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0035912 [dorsal aorta morphogenesis]
GO:0036302 [atrioventricular canal development]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060045 [positive regulation of cardiac muscle cell proliferation]
GO:0060716 [labyrinthine layer blood vessel development]
GO:0061314 [Notch signaling involved in heart development]
GO:0061419 [positive regulation of transcription from RNA polymerase II promoter in response to hypoxia]
GO:0072554 [blood vessel lumenization]
GO:0097101 [blood vessel endothelial cell fate specification]
GO:1901186 [positive regulation of ERBB signaling pathway]
GO:1901189 [positive regulation of ephrin receptor signaling pathway]
GO:2000138 [positive regulation of cell proliferation involved in heart morphogenesis]
Show all
 486 aa
54.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.