Expression of POLR2J3 in cancer - Summary - The Human Protein Atlas

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POLR2J3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	POLR2J3
Gene description	Polymerase (RNA) II (DNA directed) polypeptide J3
Protein class	Predicted intracellular proteins RNA polymerase related proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Nuclear or cytoplasmic expression in selected tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Caution, targets protein from more than one gene.
Reliability score	Approved based on 4 antibodies. HPA011403 , HPA042997 , HPA044010 , HPA046970
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA011403	HPA042997	HPA044010	HPA046970

GENE INFORMATION
Gene name	POLR2J3
Synonyms
Description	Polymerase (RNA) II (DNA directed) polypeptide J3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	102537918 - 102572656
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000168255 (version 83.38)
Entrez gene	548644
UniProt
neXtProt
Antibodypedia	POLR2J3 antibodies

PROTEIN BROWSER

POLR2J3-005	POLR2J3-010	POLR2J3-012	POLR2J3-020	POLR2J3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POLR2J3-005 ENSP00000422109 ENST00000511313	E7EP90 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	76 aa 8.4 kDa	No	0
POLR2J3-010 ENSP00000421085 ENST00000513506	E7EWC6 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	274 aa 30.4 kDa	No	0
POLR2J3-012 ENSP00000421950 ENST00000513438	D6RAG0 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	73 aa 8 kDa	No	0
POLR2J3-020 ENSP00000483328 ENST00000621093	A0A0B4J2F8 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	115 aa 13.1 kDa	No	0
POLR2J3-201 ENSP00000482932 ENST00000613744	E2QRJ6 [Direct mapping] DNA-directed RNA polymerase II subunit RPB11-b2 Show all	Predicted intracellular proteins RNA polymerase related proteins Show all	GO:0001055 [RNA polymerase II activity] GO:0003677 [DNA binding] GO:0003899 [DNA-directed RNA polymerase activity] GO:0005665 [DNA-directed RNA polymerase II, core complex] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0046983 [protein dimerization activity] Show all	158 aa 17.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.