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KCNV2

GENERAL INFORMATION

Gene name

 KCNV2

Gene description

 Potassium channel, voltage gated modifier subfamily V, member 2

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (testis cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. No internal RNA expression data available for correlation.

Reliability score

 Uncertain based on 1 antibody.
HPA031131
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Skin cancer

STAINING SUMMARY
HPA031131

GENE INFORMATION

Gene name

 KCNV2 (HGNC Symbol)

Synonyms

 Kv8.2

Description

 Potassium channel, voltage gated modifier subfamily V, member 2 (HGNC Symbol)

Entrez gene summary

 Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008]

Chromosome

 9

Cytoband

 p24.2

Chromosome location (bp)

 2717502 - 2730037

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168263 (version 83.38)

Entrez gene

 169522

UniProt

 Q8TDN2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDN2

Antibodypedia

 KCNV2 antibodies

PROTEIN BROWSER
KCNV2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KCNV2-001
ENSP00000371514
ENST00000382082
Q8TDN2 [Direct mapping]
Potassium voltage-gated channel subfamily V member 2
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Voltage-gated ion channels
   Voltage-Gated Potassium Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
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GO:0005216 [ion channel activity]
GO:0005251 [delayed rectifier potassium channel activity]
GO:0005886 [plasma membrane]
GO:0006811 [ion transport]
GO:0007268 [synaptic transmission]
GO:0008076 [voltage-gated potassium channel complex]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034765 [regulation of ion transmembrane transport]
GO:0051260 [protein homooligomerization]
GO:0055085 [transmembrane transport]
GO:0071805 [potassium ion transmembrane transport]
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 545 aa
62.5 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.