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PTF1A

GENERAL INFORMATION

Gene name

 PTF1A

Gene description

 Pancreas specific transcription factor, 1a

Protein class

 Disease related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (pancreatic cancer)
HPA (cell line):Cell line enriched (U-2 OS)
HPA (normal tissue):Tissue enriched (pancreas)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (pancreatic cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PTF1A (HGNC Symbol)

Synonyms

 bHLHa29, PTF1-p48

Description

 Pancreas specific transcription factor, 1a (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 p12.2

Chromosome location (bp)

 23192327 - 23194252

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168267 (version 83.38)

Entrez gene

 256297

UniProt

 Q7RTS3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7RTS3

Antibodypedia

 PTF1A antibodies

PROTEIN BROWSER
PTF1A-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTF1A-001
ENSP00000365687
ENST00000376504
Q7RTS3 [Direct mapping]
Pancreas transcription factor 1 subunit alpha
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Predicted intracellular proteins
Transcription factors
   Basic domains
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009790 [embryo development]
GO:0009888 [tissue development]
GO:0010842 [retina layer formation]
GO:0021549 [cerebellum development]
GO:0030154 [cell differentiation]
GO:0030902 [hindbrain development]
GO:0031016 [pancreas development]
GO:0031017 [exocrine pancreas development]
GO:0031018 [endocrine pancreas development]
GO:0035881 [amacrine cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045165 [cell fate commitment]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0048384 [retinoic acid receptor signaling pathway]
GO:0048663 [neuron fate commitment]
GO:0048699 [generation of neurons]
GO:0060042 [retina morphogenesis in camera-type eye]
GO:0061074 [regulation of neural retina development]
GO:0070888 [E-box binding]
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 328 aa
35 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.