Cell atlas - FOXI1 - The Human Protein Atlas

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FOXI1

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TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli
	Vesicles

Human cell
	Nucleoli
	Vesicles

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GENERAL INFORMATION
Gene name	FOXI1
Gene description	Forkhead box I1
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli & vesicles.
RNA cell category	Cell line enhanced (MCF7)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (uncertain), Vesicles (uncertain)

DATA RELIABILITY
Reliability score	Uncertain based on 1 antibody. HPA071469
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (MCF7) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli & vesicles.

Main location

Nucleoli (uncertain), Vesicles (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA071469	HaCaT	Nucleoli
	HPA071469	HaCaT	Vesicles
	HPA071469	MCF7	Nucleoli
	HPA071469	MCF7	Vesicles
	HPA071469	U-2 OS	Nucleoli
	HPA071469	U-2 OS	Vesicles

GENE INFORMATION
Gene name	FOXI1 (HGNC Symbol)
Synonyms	FKHL10, FREAC6
Description	Forkhead box I1 (HGNC Symbol)
Entrez gene summary	This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it is possible that this gene plays an important role in the development of the cochlea and vestibulum, as well as embryogenesis. Mutations in this gene may be associated with the common cavity phenotype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.1
Chromosome location (bp)	170105897 - 170109725
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168269 (version 83.38)
Entrez gene	2299
UniProt	Q12951 (UniProt - Evidence at protein level)
neXtProt	NX_Q12951
Antibodypedia	FOXI1 antibodies

PROTEIN BROWSER

FOXI1-001	FOXI1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FOXI1-001 ENSP00000304286 ENST00000306268	Q12951 [Direct mapping] Forkhead box protein I1 E0XEN6 [Target identity:100%; Query identity:100%] Forkhead box I1; Forkhead box I1, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0042472 [inner ear morphogenesis] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	378 aa 41 kDa	No	0
FOXI1-002 ENSP00000415483 ENST00000449804	Q12951 [Direct mapping] Forkhead box protein I1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008301 [DNA binding, bending] GO:0009790 [embryo development] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	283 aa 30.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.