Expression of SMIM4 in cancer - Summary

GENERAL INFORMATION
Gene name	SMIM4
Gene description	Small integral membrane protein 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in adreanal gland and myocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA047771
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable), renal cancer (favourable) and pancreatic cancer (favourable).
Lung cancer p<0.001 Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA047771

GENE INFORMATION
Gene name	SMIM4 (HGNC Symbol)
Synonyms	C3orf78
Description	Small integral membrane protein 4 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p21.1
Chromosome location (bp)	52534013 - 52579237
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168273 (version 83.38)
Entrez gene	440957
UniProt	Q8WVI0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVI0
Antibodypedia	SMIM4 antibodies

PROTEIN BROWSER

SMIM4-001	SMIM4-002	SMIM4-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SMIM4-001 ENSP00000417806 ENST00000477703	Q8WVI0 [Direct mapping] Small integral membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	70 aa 8.7 kDa	No	1
SMIM4-002 ENSP00000305661 ENST00000307106	F8W7Q2 [Direct mapping] Small integral membrane protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		37 aa 4.4 kDa	No	0
SMIM4-006 ENSP00000418000 ENST00000476842	C9JAX8 [Direct mapping] Small integral membrane protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	59 aa 7 kDa	No	1