Cell atlas - PXK - The Human Protein Atlas

GENERAL INFORMATION
Gene name	PXK
Gene description	PX domain containing serine/threonine kinase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the plasma membrane & cytosol. In addition localized to the microtubule organizing center.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (supported), Cytosol (supported)
Additional location	In addition localized to the Microtubule organizing center (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA024068
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the plasma membrane & cytosol. In addition localized to the microtubule organizing center.

Main location

Plasma membrane (supported), Cytosol (supported)

Additional location

Microtubule organizing center (supported)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA024068	A-431	Plasma membrane
		Microtubule organizing center
		Cytosol
HPA024068	U-2 OS	No staining
HPA024068	U-251 MG	Cytosol

GENE INFORMATION
Gene name	PXK (HGNC Symbol)
Synonyms	FLJ20335
Description	PX domain containing serine/threonine kinase (HGNC Symbol)
Entrez gene summary	This gene encodes a phox (PX) domain-containing protein which may be involved in synaptic transmission and the ligand-induced internalization and degradation of epidermal growth factors. Variations in this gene may be associated with susceptibility to systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	58332880 - 58426126
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168297 (version 83.38)
Entrez gene	54899
UniProt	Q7Z7A4 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z7A4
Antibodypedia	PXK antibodies

PROTEIN BROWSER

PXK-001	PXK-002	PXK-003	PXK-004	PXK-005	PXK-006	PXK-009	PXK-010	PXK-011	PXK-012	PXK-201	PXK-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PXK-001 ENSP00000348472 ENST00000356151	Q7Z7A4 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0008022 [protein C-terminus binding] GO:0032780 [negative regulation of ATPase activity] GO:0035091 [phosphatidylinositol binding] GO:0042391 [regulation of membrane potential] GO:0043234 [protein complex] GO:0043271 [negative regulation of ion transport] GO:0050804 [modulation of synaptic transmission] Show all	578 aa 64.9 kDa	No	0
PXK-002 ENSP00000417903 ENST00000463280	E9PD56 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] Show all	482 aa 54.7 kDa	No	0
PXK-003 ENSP00000418836 ENST00000493474	H7C529 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		50 aa 5.2 kDa	No	0
PXK-004 ENSP00000417915 ENST00000484288	Q7Z7A4 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0008022 [protein C-terminus binding] GO:0032780 [negative regulation of ATPase activity] GO:0035091 [phosphatidylinositol binding] GO:0042391 [regulation of membrane potential] GO:0043271 [negative regulation of ion transport] GO:0050804 [modulation of synaptic transmission] Show all	515 aa 58.7 kDa	No	0
PXK-005 ENSP00000418376 ENST00000495557	H7C4W2 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		85 aa 9.4 kDa	No	0
PXK-006 ENSP00000419049 ENST00000479241	A0A0C4DG95 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] Show all	563 aa 63.8 kDa	No	0
PXK-009 ENSP00000418202 ENST00000479134	H7C4V0 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] Show all	312 aa 34.7 kDa	No	0
PXK-010 ENSP00000373221 ENST00000383715	H7BYG4 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] Show all	498 aa 56.7 kDa	No	0
PXK-011 ENSP00000418831 ENST00000491164	C9IYJ2 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0035091 [phosphatidylinositol binding] Show all	113 aa 13.1 kDa	No	0
PXK-012 ENSP00000476179 ENST00000459676	U3KQS4 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		203 aa 22.6 kDa	No	0
PXK-201 ENSP00000305045 ENST00000302779	W5RWE6 [Direct mapping] PX domain-containing protein kinase-like protein; PXK Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0006468 [protein phosphorylation] GO:0035091 [phosphatidylinositol binding] Show all	557 aa 63.1 kDa	No	0
PXK-202 ENSP00000373222 ENST00000383716	Q7Z7A4 [Direct mapping] PX domain-containing protein kinase-like protein Show all	Enzymes Kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003779 [actin binding] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005815 [microtubule organizing center] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0006954 [inflammatory response] GO:0008022 [protein C-terminus binding] GO:0032780 [negative regulation of ATPase activity] GO:0035091 [phosphatidylinositol binding] GO:0042391 [regulation of membrane potential] GO:0043271 [negative regulation of ion transport] GO:0050804 [modulation of synaptic transmission] Show all	515 aa 58.7 kDa	No	0