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HIST1H1E

GENERAL INFORMATION

Gene name

 HIST1H1E

Gene description

 Histone cluster 1, H1e

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-87 MG)
HPA (normal tissue):Tissue enriched (bone marrow)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Caution, targets protein from more than one gene. External characterization data supports antibody staining.

Reliability score

 Supported based on 2 antibodies.
HPA055907 , CAB011506
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA055907
CAB011506

GENE INFORMATION

Gene name

 HIST1H1E (HGNC Symbol)

Synonyms

 H1.4, H1e, H1F4, H1s-4

Description

 Histone cluster 1, H1e (HGNC Symbol)

Entrez gene summary

 Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]

Chromosome

 6

Cytoband

 p22.2

Chromosome location (bp)

 26156354 - 26157107

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168298 (version 83.38)

Entrez gene

 3008

UniProt

 P10412 (UniProt - Evidence at protein level)

neXtProt

 NX_P10412

Antibodypedia

 HIST1H1E antibodies

PROTEIN BROWSER
HIST1H1E-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIST1H1E-001
ENSP00000307705
ENST00000304218
P10412 [Direct mapping]
Histone H1.4
A3R0T8 [Target identity:100%; Query identity:100%]
Histone 1, H1e; Histone H1e
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Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000786 [nucleosome]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005720 [nuclear heterochromatin]
GO:0006334 [nucleosome assembly]
GO:0016584 [nucleosome positioning]
GO:0031490 [chromatin DNA binding]
GO:0044822 [poly(A) RNA binding]
GO:0070062 [extracellular exosome]
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 219 aa
21.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.