Expression of KCTD6 in cancer - Summary - The Human Protein Atlas

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KCTD6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KCTD6
Gene description	Potassium channel tetramerization domain containing 6
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues including cerebellum and seminal vesicle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA036100 , HPA036101
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (favourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA036100	HPA036101

GENE INFORMATION
Gene name	KCTD6 (HGNC Symbol)
Synonyms	KCASH3, MGC27385
Description	Potassium channel tetramerization domain containing 6 (HGNC Symbol)
Entrez gene summary
Chromosome	3
Cytoband	p14.3
Chromosome location (bp)	58492114 - 58502360
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168301 (version 83.38)
Entrez gene	200845
UniProt	Q8NC69 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NC69
Antibodypedia	KCTD6 antibodies

PROTEIN BROWSER

KCTD6-001	KCTD6-002	KCTD6-003	KCTD6-004	KCTD6-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KCTD6-001 ENSP00000347188 ENST00000355076	Q8NC69 [Direct mapping] BTB/POZ domain-containing protein KCTD6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030506 [ankyrin binding] GO:0051260 [protein homooligomerization] Show all	237 aa 27.6 kDa	No	0
KCTD6-002 ENSP00000417490 ENST00000490264	Q8NC69 [Direct mapping] BTB/POZ domain-containing protein KCTD6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030506 [ankyrin binding] GO:0051260 [protein homooligomerization] Show all	237 aa 27.6 kDa	No	0
KCTD6-003 ENSP00000418999 ENST00000479179		Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		9 aa 1.1 kDa	No	0
KCTD6-004 ENSP00000442507 ENST00000491093	F5H7I0 [Direct mapping] BTB/POZ domain-containing protein KCTD6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0051260 [protein homooligomerization] Show all	74 aa 8.3 kDa	No	0
KCTD6-005 ENSP00000384948 ENST00000404589	Q8NC69 [Direct mapping] BTB/POZ domain-containing protein KCTD6 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0030506 [ankyrin binding] GO:0051260 [protein homooligomerization] Show all	237 aa 27.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.