Expression of MPLKIP in cancer - Summary - The Human Protein Atlas

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MPLKIP

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MPLKIP
Gene description	M-phase specific PLK1 interacting protein
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA058457
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA058457

GENE INFORMATION
Gene name	MPLKIP (HGNC Symbol)
Synonyms	C7orf11, ORF20, TTDN1
Description	M-phase specific PLK1 interacting protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene localizes to the centrosome during mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]
Chromosome	7
Cytoband	p14.1
Chromosome location (bp)	40126023 - 40134659
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168303 (version 83.38)
Entrez gene	136647
UniProt	Q8TAP9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TAP9
Antibodypedia	MPLKIP antibodies

PROTEIN BROWSER

MPLKIP-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MPLKIP-001 ENSP00000304553 ENST00000306984	Q8TAP9 [Direct mapping] M-phase-specific PLK1-interacting protein A4D1W6 [Target identity:100%; Query identity:100%] Chromosome 7 open reading frame 11; cDNA FLJ76008 Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0005813 [centrosome] GO:0007067 [mitotic nuclear division] GO:0030496 [midbody] GO:0051301 [cell division] Show all	179 aa 19.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.