Expression of CX3CR1 in cancer - Summary - The Human Protein Atlas

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CX3CR1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CX3CR1
Gene description	Chemokine (C-X3-C motif) receptor 1
Protein class	Disease related genes G-protein coupled receptors Plasma proteins Potential drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Cell line enriched (RPMI-8226)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including cerebral cortex.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA046587 , CAB032478
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA046587	CAB032478

GENE INFORMATION
Gene name	CX3CR1 (HGNC Symbol)
Synonyms	CCRL1, CMKBRL1, CMKDR1, GPR13, V28
Description	Chemokine (C-X3-C motif) receptor 1 (HGNC Symbol)
Entrez gene summary	Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Chromosome	3
Cytoband	p22.2
Chromosome location (bp)	39263494 - 39281735
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000168329 (version 83.38)
Entrez gene	1524
UniProt	P49238 (UniProt - Evidence at protein level)
neXtProt	NX_P49238
Antibodypedia	CX3CR1 antibodies

PROTEIN BROWSER

CX3CR1-001	CX3CR1-003	CX3CR1-004	CX3CR1-201	CX3CR1-202	CX3CR1-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CX3CR1-001 ENSP00000382166 ENST00000399220	P49238 [Direct mapping] CX3C chemokine receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009611 [response to wounding] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 40.4 kDa	No	7
CX3CR1-003 ENSP00000394960 ENST00000435290	C9JN40 [Direct mapping] CX3C chemokine receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016495 [C-X3-C chemokine receptor activity] GO:0070098 [chemokine-mediated signaling pathway] Show all	166 aa 18.4 kDa	No	4
CX3CR1-004 ENSP00000408835 ENST00000412814	C9JLM2 [Direct mapping] CX3C chemokine receptor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0006935 [chemotaxis] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0016495 [C-X3-C chemokine receptor activity] GO:0070098 [chemokine-mediated signaling pathway] Show all	106 aa 11.9 kDa	No	2
CX3CR1-201 ENSP00000351059 ENST00000358309	P49238 [Direct mapping] CX3C chemokine receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0001774 [microglial cell activation] GO:0002052 [positive regulation of neuroblast proliferation] GO:0002282 [microglial cell activation involved in immune response] GO:0002881 [negative regulation of chronic inflammatory response to non-antigenic stimulus] GO:0004896 [cytokine receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007613 [memory] GO:0009611 [response to wounding] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0016495 [C-X3-C chemokine receptor activity] GO:0016525 [negative regulation of angiogenesis] GO:0019221 [cytokine-mediated signaling pathway] GO:0021795 [cerebral cortex cell migration] GO:0030336 [negative regulation of cell migration] GO:0032809 [neuronal cell body membrane] GO:0043005 [neuron projection] GO:0045766 [positive regulation of angiogenesis] GO:0048246 [macrophage chemotaxis] GO:0048471 [perinuclear region of cytoplasm] GO:0070098 [chemokine-mediated signaling pathway] GO:0071222 [cellular response to lipopolysaccharide] GO:0071560 [cellular response to transforming growth factor beta stimulus] GO:1900272 [negative regulation of long-term synaptic potentiation] GO:2001240 [negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] Show all	387 aa 44 kDa	No	7
CX3CR1-202 ENSP00000439140 ENST00000541347	P49238 [Direct mapping] CX3C chemokine receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009611 [response to wounding] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 40.4 kDa	No	7
CX3CR1-203 ENSP00000444928 ENST00000542107	P49238 [Direct mapping] CX3C chemokine receptor 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Chemokines and chemotactic factors receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0004950 [chemokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006935 [chemotaxis] GO:0006968 [cellular defense response] GO:0007155 [cell adhesion] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0009611 [response to wounding] GO:0016021 [integral component of membrane] GO:0016032 [viral process] GO:0070098 [chemokine-mediated signaling pathway] Show all	355 aa 40.4 kDa	No	7

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