Expression of C8orf22 in cancer - Summary - The Human Protein Atlas

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C8orf22

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C8orf22
Gene description	Chromosome 8 open reading frame 22
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, renal cancer)
HPA (cell line):	Cell line enriched (HEL)
HPA (normal tissue):	Tissue enriched (skeletal muscle)

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

RNA data suggests expression in skeletal muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA060329
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, renal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA060329

GENE INFORMATION
Gene name	C8orf22
Synonyms
Description	Chromosome 8 open reading frame 22 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q11.21
Chromosome location (bp)	49054311 - 49076090
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000168333 (version 83.38)
Entrez gene	492307
UniProt	Q8WWR9 (UniProt - Inferred from homology)
neXtProt	NX_Q8WWR9
Antibodypedia	C8orf22 antibodies

PROTEIN BROWSER

C8orf22-001	C8orf22-002	C8orf22-003	C8orf22-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C8orf22-001 ENSP00000382561 ENST00000399653	Q8WWR9 [Direct mapping] Pancreatic progenitor cell differentiation and proliferation factor-like protein Show all	Predicted intracellular proteins Show all	GO:0001708 [cell fate specification] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0031017 [exocrine pancreas development] Show all	81 aa 8.9 kDa	No	0
C8orf22-002 ENSP00000304926 ENST00000303202	Q8WWR9 [Direct mapping] Pancreatic progenitor cell differentiation and proliferation factor-like protein Show all	Predicted intracellular proteins Show all	GO:0001708 [cell fate specification] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0031017 [exocrine pancreas development] Show all	84 aa 9.2 kDa	No	0
C8orf22-003 ENSP00000430392 ENST00000517663	Q8WWR9 [Direct mapping] Pancreatic progenitor cell differentiation and proliferation factor-like protein Show all	Predicted intracellular proteins Show all	GO:0001708 [cell fate specification] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0031017 [exocrine pancreas development] Show all	84 aa 9.3 kDa	No	0
C8orf22-004 ENSP00000428773 ENST00000522267	Q8WWR9 [Direct mapping] Pancreatic progenitor cell differentiation and proliferation factor-like protein Show all	Predicted intracellular proteins Show all	GO:0001708 [cell fate specification] GO:0007275 [multicellular organismal development] GO:0030154 [cell differentiation] GO:0031017 [exocrine pancreas development] Show all	84 aa 9.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.