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SEPT2

GENERAL INFORMATION

Gene name

 SEPT2

Gene description

 Septin 2

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 23
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA018481 , CAB017190
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 SEPT2 (HGNC Symbol)

Synonyms

 DIFF6, hNedd5, KIAA0158, NEDD5, Pnutl3

Description

 Septin 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241315100 - 241354027

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168385 (version 83.38)

Entrez gene

 4735

UniProt

 Q15019 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15019

Antibodypedia

 SEPT2 antibodies

PROTEIN BROWSER
«
SEPT2-001
SEPT2-002
SEPT2-004
SEPT2-005
SEPT2-007
SEPT2-008
SEPT2-009
SEPT2-012
SEPT2-013
SEPT2-014
SEPT2-021
SEPT2-023
SEPT2-026
SEPT2-031
SEPT2-034
SEPT2-036
SEPT2-037
SEPT2-039
SEPT2-040
SEPT2-042
SEPT2-046
SEPT2-047
SEPT2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SEPT2-001
ENSP00000353157
ENST00000360051
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0042384 [cilium assembly]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 361 aa
41.5 kDa 		No 0
SEPT2-002
ENSP00000375834
ENST00000391973
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0042384 [cilium assembly]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 361 aa
41.5 kDa 		No 0
SEPT2-004
ENSP00000385109
ENST00000401990
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0042384 [cilium assembly]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 371 aa
42.7 kDa 		No 0
SEPT2-005
ENSP00000384525
ENST00000407971
B5MCX3 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0007049 [cell cycle]
GO:0015629 [actin cytoskeleton]
GO:0051301 [cell division]
Show all
 321 aa
36.9 kDa 		No 0
SEPT2-007
ENSP00000375832
ENST00000391971
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0042384 [cilium assembly]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 361 aa
41.5 kDa 		No 0
SEPT2-008
ENSP00000385172
ENST00000402092
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000777 [condensed chromosome kinetochore]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0015629 [actin cytoskeleton]
GO:0030496 [midbody]
GO:0032154 [cleavage furrow]
GO:0042384 [cilium assembly]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 361 aa
41.5 kDa 		No 0
SEPT2-009
ENSP00000397195
ENST00000428282
C9J2Q4 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0007049 [cell cycle]
GO:0051301 [cell division]
Show all
 184 aa
21.1 kDa 		No 0
SEPT2-012
ENSP00000404484
ENST00000445030
C9JFT1 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 72 aa
7.9 kDa 		No 0
SEPT2-013
ENSP00000389174
ENST00000428524
C9JT15 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 50 aa
5.5 kDa 		No 0
SEPT2-014
ENSP00000386001
ENST00000407017
B5MD47 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 94 aa
10.3 kDa 		No 0
SEPT2-021
ENSP00000406181
ENST00000436795
C9J938 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 148 aa
16.8 kDa 		No 0
SEPT2-023
ENSP00000394666
ENST00000411484
C9JQJ4 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 147 aa
16.6 kDa 		No 0
SEPT2-026
ENSP00000399767
ENST00000434955
C9JZI2 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 105 aa
11.6 kDa 		No 0
SEPT2-031
ENSP00000413031
ENST00000441533
C9JFT1 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 72 aa
7.9 kDa 		No 0
SEPT2-034
ENSP00000412434
ENST00000437066
C9IZU3 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 131 aa
14.8 kDa 		No 0
SEPT2-036
ENSP00000404417
ENST00000429791
C9JG93 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 23 aa
2.6 kDa 		No 0
SEPT2-037
ENSP00000409596
ENST00000420786
C9JSE7 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 52 aa
5.7 kDa 		No 0
SEPT2-039
ENSP00000391717
ENST00000449239
C9JB25 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 173 aa
19.6 kDa 		No 0
SEPT2-040
ENSP00000399195
ENST00000443492
C9IY94 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 121 aa
13.7 kDa 		No 0
SEPT2-042
ENSP00000408902
ENST00000457874
H7C310 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
Show all
 161 aa
18.6 kDa 		No 0
SEPT2-046
ENSP00000408296
ENST00000421717
H7C2Y0 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0007049 [cell cycle]
GO:0051301 [cell division]
Show all
 188 aa
21.6 kDa 		No 0
SEPT2-047
ENSP00000402256
ENST00000451310
H7C1T1 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 29 aa
3 kDa 		No 0
SEPT2-201
ENSP00000479861
ENST00000616972
Q15019 [Direct mapping]
Septin-2
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000145 [exocyst]
GO:0000777 [condensed chromosome kinetochore]
GO:0002036 [regulation of L-glutamate transport]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005819 [spindle]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0007067 [mitotic nuclear division]
GO:0007224 [smoothened signaling pathway]
GO:0009986 [cell surface]
GO:0015629 [actin cytoskeleton]
GO:0030234 [enzyme regulator activity]
GO:0030496 [midbody]
GO:0031175 [neuron projection development]
GO:0032154 [cleavage furrow]
GO:0032880 [regulation of protein localization]
GO:0032947 [protein complex scaffold]
GO:0035869 [ciliary transition zone]
GO:0042384 [cilium assembly]
GO:0042995 [cell projection]
GO:0043209 [myelin sheath]
GO:0045202 [synapse]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050790 [regulation of catalytic activity]
GO:0051301 [cell division]
GO:0060170 [ciliary membrane]
GO:0070062 [extracellular exosome]
Show all
 396 aa
45.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.