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ATG4B

GENERAL INFORMATION

Gene name

 ATG4B

Gene description

 Autophagy related 4B, cysteine peptidase

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB037195
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), colorectal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001
Colorectal cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB037195

GENE INFORMATION

Gene name

 ATG4B (HGNC Symbol)

Synonyms

 APG4B, AUTL1, DKFZp586D1822, KIAA0943

Description

 Autophagy related 4B, cysteine peptidase (HGNC Symbol)

Entrez gene summary

 Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q37.3

Chromosome location (bp)

 241637213 - 241673857

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000168397 (version 83.38)

Entrez gene

 23192

UniProt

 Q9Y4P1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4P1

Antibodypedia

 ATG4B antibodies

PROTEIN BROWSER
ATG4B-001
ATG4B-002
ATG4B-006
ATG4B-015
ATG4B-020
ATG4B-023
ATG4B-025
ATG4B-026
ATG4B-027
ATG4B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ATG4B-001
ENSP00000383964
ENST00000405546
Q9Y4P1 [Direct mapping]
Cysteine protease ATG4B
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0010508 [positive regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
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 380 aa
42.6 kDa 		No 0
ATG4B-002
ENSP00000384259
ENST00000404914
Q9Y4P1 [Direct mapping]
Cysteine protease ATG4B
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0010508 [positive regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0045732 [positive regulation of protein catabolic process]
GO:0051697 [protein delipidation]
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 393 aa
44.3 kDa 		No 0
ATG4B-006
ENSP00000384661
ENST00000402096
Q9Y4P1 [Direct mapping]
Cysteine protease ATG4B
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Enzymes
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000045 [autophagosome assembly]
GO:0000422 [mitophagy]
GO:0004175 [endopeptidase activity]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006508 [proteolysis]
GO:0006612 [protein targeting to membrane]
GO:0006914 [autophagy]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008234 [cysteine-type peptidase activity]
GO:0010508 [positive regulation of autophagy]
GO:0016236 [macroautophagy]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 331 aa
37 kDa 		No 0
ATG4B-015
ENSP00000400050
ENST00000419606
C9J1C1 [Direct mapping]
Cysteine protease ATG4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 66 aa
7.7 kDa 		No 0
ATG4B-020
ENSP00000407389
ENST00000430617
C9JVD5 [Direct mapping]
Cysteine protease ATG4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
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 105 aa
12.1 kDa 		No 0
ATG4B-023
ENSP00000409895
ENST00000425239
C9JQ72 [Direct mapping]
Cysteine protease ATG4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 266 aa
30.2 kDa 		No 0
ATG4B-025
ENSP00000383582
ENST00000400771
C9JIK8 [Direct mapping]
Cysteine protease ATG4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 219 aa
24.8 kDa 		No 0
ATG4B-026
ENSP00000410526
ENST00000429899
C9J3C0 [Direct mapping]
Cysteine protease ATG4B
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 147 aa
16.6 kDa 		No 0
ATG4B-027
ENSP00000404783
ENST00000428861
H7C2A6 [Direct mapping]
Cysteine protease ATG4B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 193 aa
21.2 kDa 		No 0
ATG4B-201
ENSP00000487133
ENST00000625810
F2Z2K8 [Direct mapping]
Cysteine protease ATG4B
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000422 [mitophagy]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005829 [cytosol]
GO:0006501 [C-terminal protein lipidation]
GO:0006612 [protein targeting to membrane]
GO:0006995 [cellular response to nitrogen starvation]
GO:0016485 [protein processing]
GO:0044804 [nucleophagy]
GO:0051697 [protein delipidation]
Show all
 88 aa
10.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.